Acute effect of equicaloric meals varying in glycemic index and glycemic load on arterial stiffness and glycemia in healthy adults: a randomized crossover trial

European Journal of Clinical Nutrition
Andreea ZurbauVladimir Vuksan

Abstract

Dietary carbohydrate quality and quantity fluctuate but it is unknown which attribute takes precedence in vascular health preservation. We investigated all four permutations of glycemic index (GI) and glycemic load (GL) on acute vascular and glycemic responses. Twenty-one healthy adults were screened for this crossover trial. Seventeen (8 M:9 F; 26.7 ± 12.3 y; BMI 22.2 ± 2.8 kg/m2) entered randomization and completed the study, receiving four isocaloric meals, varying in GI and GL, in random order at least 3 days apart. The four meals included either chickpeas (GI = 28, GL = 14, 50 g available carbohydrates (CHO)), a small potato portion (GI = 85, GL = 14, CHO = 17 g), pasta (GI = 45, GL = 42, CHO = 94 g) or a large potato portion (GI = 85, GL = 42, CHO = 50 g) as the source of carbohydrate. Augmentation index (AIx) and central and peripheral blood pressure were measured fasting, 1, 2, 3, and 4 h post-consumption. Capillary blood glucose was analyzed fasting, 15, 30, 45, 60, 90, 120, 180, and 240 min. A reduction in AIx from baseline was observed 4 h following the chickpeas (low GI-low GL) (p = 0.046). The incremental area under blood glucose curves were significantly higher 2 h post-consumption following high compared with low...Continue Reading

References

Nov 1, 1991·The American Journal of Clinical Nutrition·T M WoleverR G Josse
Sep 1, 1987·The American Journal of Clinical Nutrition·G A SpillerJ Scala
Mar 1, 1981·The American Journal of Clinical Nutrition·D J JenkinsD V Goff
Feb 1, 1984·Physiology & Behavior·H R KissileffH A Jordan
Mar 10, 2001·Physiology & Behavior·A L SawayaS B Roberts
Feb 6, 2002·Circulation·Guido ArcaroRiccardo C Bonadonna
May 26, 2004·The American Journal of Clinical Nutrition·Cees de GraafHenk F J Hendriks
May 6, 2006·International Journal of Cardiology·Jerry R GreenfieldLesley V Campbell
Jun 19, 2007·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Net Das Evcimen, George L King
Sep 24, 2008·The Journal of Experimental Medicine·Assam El-OstaMichael Brownlee
Jun 19, 2009·The American Journal of Clinical Nutrition·Kiran D K AhujaMadeleine J Ball
Oct 19, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Dick H J ThijssenDaniel J Green
Mar 24, 2012·The American Journal of Cardiology·Jia-Yi DongLi-Qiang Qin
Nov 1, 2012·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Silvio BuscemiGiovam Battista Rini
Sep 5, 2013·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Anna C Roberts, Karen E Porter
Oct 16, 2014·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·J I Recio-RodriguezUNKNOWN EVIDENT Group
Jan 17, 2015·Asia-Pacific Journal of Public Health·Xianlei CaiFang Ding

❮ Previous
Next ❯

Clinical Trials Mentioned

NCT01883700

Software Mentioned

Statistical Analysis System

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.