Acute effect of ethanol on 7-hydroperoxycholesterol in muscle and liver

Lipids
J AdachiV R Preedy

Abstract

We tested the hypotheses that ethanol sensitivities of muscle and liver can be discerned in the initial periods of ethanol exposure, especially when acetaldehyde levels are markedly raised with cyanamide, an aldehyde dehydrogenase inhibitor. To test this, we measured cholesterol hydroperoxides in soleus (Type I) and plantaris (Type II) muscle in four groups of rats acutely (i.e., 2.5 h) exposed to: [S] saline (control), [Cy] cyanamide, [EtOH] ethanol, or [Cy + EtOH] cyanamide + ethanol. Comparative reference was also made to the response of the liver. After 2.5 h, ethanol alone significantly increased 7 alpha-hydroperoxycholest-5-en-3 beta-ol (7 alpha-OOH) and 7 beta-hydroperoxycholest-5-en-3 beta-ol (7 beta-OOH) levels in plantaris muscle. Identical qualitative effects were seen in rats treated with cyanamide + ethanol, but there was no discernible difference between groups [EtOH] and [Cy + EtOH]. In both the soleus muscle and liver, none of the treatments with either ethanol or cyanamide + ethanol had any effect on any of the measured parameters. This is the first report of a differential response of 7 alpha-OOH and 7 beta-OOH in Type II, compared to Type I predominant muscles, and the first time that muscle has been shown to...Continue Reading

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Citations

Dec 1, 2001·Free Radical Biology & Medicine·R KudoK Yoshida
Nov 25, 2003·The Journal of Nutritional Biochemistry·Junko AdachiVictor R Preedy
Mar 6, 2009·Legal Medicine·Migiwa AsanoYasuhiro Ueno
Dec 24, 2003·Alcoholism, Clinical and Experimental Research·Onni NiemeläVictor R Preedy
Jan 11, 2002·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·V R PreedyT J Peters
Apr 18, 2003·Metabolism: Clinical and Experimental·A B BonnerV R Preedy
Sep 1, 2005·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Vinood B PatelVictor R Preedy
Jul 24, 2003·American Journal of Physiology. Endocrinology and Metabolism·Tatsuo NakaharaVictor R Preedy

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