PMID: 18187428Jan 12, 2008Paper

Acute effect of poly-gamma-glutamic acid on calcium absorption in post-menopausal women

Journal of the American College of Nutrition
H TanimotoSusan J Fairweather-Tait

Abstract

Poly-gamma-glutamic acid (PGA) increases calcium (Ca) solubility in vitro and in vivo, and is associated with reduced bone loss in post-menopausal Japanese women. This study is the first to examine the effect of PGA on Ca absorption in humans. A single-blind, randomized, crossover study with a 3-4 week wash-out was performed to determine the effect of PGA (80.6% glutamic acids) on Ca absorption measured by the double stable isotope method. Twenty-four healthy, non-smoking, postmenopausal women (mean age: 56.4 +/- SE 0.9) were given 200 g of orange juice containing 200 mg Ca as Ca-44 enriched CaCO(3), with or without 60 mg of PGA, after an overnight fast. The two tests were separated by 3-4 weeks. An intravenous injection of Ca-42 (CaCl(2) solution) was given 30 min after consuming the drink and a complete urine collection carried out from 24-48 h post-dosing. Ca absorption was calculated from the Ca isotope ratios measured by thermal ionization quadrupole mass spectrometry (TIQMS). Mean Ca absorption with PGA was significantly higher (P < 0.01) than without PGA, 39.1 (SE 1.6) % and 34.6 (SE 1.9) %, respectively. The effect of PGA on increasing Ca absorption was more marked in a sub-group of subjects whose baseline Ca absorption...Continue Reading

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Citations

Oct 8, 2014·Microbiology·Adetoro OgunleyeIza Radecka
Mar 8, 2011·Bioresource Technology·Ishwar Bajaj, Rekha Singhal
Jul 22, 2019·Archives of Oral Biology·Zeeshan QamarTayyaba Zeeshan
Jun 8, 2021·Nutrition Research and Practice·Carolina García-García, Inkyung Baik

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