Acute effects of 1-octen-3-ol, a microbial volatile organic compound (MVOC)--an experimental study

Toxicology Letters
Robert WålinderG Johanson

Abstract

Acute effects were assessed from exposure to a common volatile compound of microbial origin, the aliphatic alcohol 1-octen 3-ol (octenol). Twenty-nine volunteers performed symptom reports, measurement of blink frequency by electromyography, measurement of the eye break-up time, vital staining of the eye, nasal lavage, acoustic rhinometry, transfer tests and dynamic spirometry. Subjects were during 2h in random order exposed to either 10mg/m(3) of octenol or clean air as control. During octenol exposure subjective ratings of smell and nasal irritation were increased together with higher nasal lavage biomarker levels of eosinophil cationic protein, myeloperoxidase and lysozyme. Also eye irritation and blinking frequency were increased together with throat irritation, mild dyspnoea after 1-h but not after 2-h, and a small decrease in vital capacity. Ratings of headache and nausea were also increased. Atopics did not have more reactions due to exposure, whereas females experienced more smell and mucosal irritation. Thus, there were both subjective and objective signs of mild mucosal irritation of eyes and airways together with symptoms of headache and nausea.

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Citations

Nov 13, 2013·Proceedings of the National Academy of Sciences of the United States of America·Arati A InamdarJoan Wennstrom Bennett
Jun 16, 2010·International Archives of Occupational and Environmental Health·Gunilla Wieslander, Dan Norbäck
Jul 21, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Arati A InamdarJoan Wennstrom Bennett
Sep 25, 2015·Toxins·Joan W Bennett, Arati A Inamdar
Feb 23, 2011·Journal of Medical Entomology·M C PintoA E Eiras
Sep 8, 2012·International Journal of Hygiene and Environmental Health·Peder Wolkoff
Aug 14, 2012·Indoor Air·L ErnstgårdG Johanson
Apr 5, 2016·Environmental Research·Hyunok ChoiCarl-Gustaf Bornehag
May 29, 2015·Biotechnology Letters·Rumi KonumaMakoto Yoshida
Apr 9, 2015·Frontiers in Microbiology·Joan W Bennett
Dec 17, 2014·Seminars in Immunopathology·Gaëlle VacherThierry Roger
Jan 27, 2018·Mycobiology·Hadeel Saeed Al-MalikiJoan W Bennett
Apr 22, 2015·Mycobiology·Kayla K PennermanJoan Wennstrom Bennett
Sep 10, 2020·Annual Review of Microbiology·Arati A InamdarJoan W Bennett
Sep 13, 2019·Archives of Toxicology·Kirsten SuckerThomas Brüning
May 2, 2019·American Journal of Physiology. Renal Physiology·Victoria L Halperin KuhnsJennifer L Pluznick
Nov 13, 2010·Human & Experimental Toxicology·Richard GminskiVolker Mersch-Sundermann
Sep 6, 2020·Ecotoxicology and Environmental Safety·Giulianna Echeverria MacedoThaís Posser

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