PMID: 3746286Jan 1, 1986Paper

Acute effects of aspartame on systolic blood pressure in spontaneously hypertensive rats

Journal of Neural Transmission
P J Kiritsy, T J Maher

Abstract

Exogenous tyrosine lowers blood pressure in spontaneously hypertensive rats (SHR). The artificial sweetener aspartame also elevates blood and brain tyrosine levels in rats by being hydrolyzed to phenylalanine, which is then rapidly hydroxylated to tyrosine in the liver. Hence we tested the ability of aspartame; its hydrolytic products phenylalanine, aspartic acid and methanol; and of tyrosine itself to lower blood pressure in SHR. For one week prior to experimentation rats were acclimated to the indirect blood pressure measurement technique; on the day of an experiment they received I.P. injections (mg/kg) of aspartame (12.5-200), tyrosine (25-200) or phenylalanine (100-200), or of aspartic acid or methanol in the doses theoretically contained within 200 mg/kg aspartame. Animals receiving 50, 100 or 200 mg/kg of aspartame exhibited maximum falls in blood pressure of 17.3, 24.2 and 19.3 mmHg, respectively. All changes were significant, as determined by ANOVA and the Newman-Keuls test (p less than 0.05). Tyrosine or phenylalanine also lowered blood pressure, but aspartic acid or methanol produced no significant effects. Co-administration of aspartame with valine, a large neutral amino acid that competes with phenylalanine or tyro...Continue Reading

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Citations

Jan 1, 1987·Journal of Neural Transmission·R J Wurtman, T J Maher
Jan 31, 1989·European Journal of Pharmacology·D L Yourick, R E Tessel
Nov 14, 1997·Pharmacology & Toxicology·N Hutri-KähönenM Kähönen
Sep 18, 2015·Neural Computation·Takashi Takenouchi

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