PMID: 7008735Feb 23, 1981Paper

Acute effects of aspirin and acetaminophen on renal function

Archives of Internal Medicine
P H Plotz, R P Kimberly

Abstract

The renal effects of aspirin and acetaminophen are minor. With a major overdose of acetaminophen, uncommonly renal failure may occur that cannot be ascribed to hepatic failure; its mechanism is unknown. Aspirin may cause a transient shedding of renal tubular cells, alterations in urate excretion, inhibition of spironolactone action, and, in certain clinical settings, a reversible decline in renal function manifested as a fall in glomerular filtration that may be accompanied by mild water, sodium, and potassium retention. Active systemic lupus erythematosus, advanced cirrhosis, and chronic renal insufficiency seem to predispose patients to the effects on renal function, and there is direct or indirect evidence in those conditions that prostaglandin synthesis is an important part of the body's attempt to preserve renal blood flow. Study of these effects has provided new insight into the way in which the kidneys may use prostaglandins to preserve renal function when it is threatened.

Citations

Mar 1, 1990·British Journal of Clinical Pharmacology·H Bippi, J C Frölich
Jun 1, 1982·The Journal of Clinical Investigation·P PatrignaniC Patrono
Jan 1, 1991·Journal of Clinical Epidemiology·A C HauserP Balcke
Aug 8, 1981·Lancet
Nov 14, 1983·The American Journal of Medicine·R S Nanra
Jan 1, 1985·Diabetic Medicine : a Journal of the British Diabetic Association·J S ChristiansenH H Parving
Mar 1, 1988·Diabetic Medicine : a Journal of the British Diabetic Association·E R MathiesenH H Parving
Mar 18, 2005·The Journal of Pain : Official Journal of the American Pain Society·Vincent Launay-VacherGilbert Deray
Jun 1, 1984·Naunyn-Schmiedeberg's Archives of Pharmacology·U DienerU Klotz
Jun 22, 2002·The Cochrane Database of Systematic Reviews·M Meremikwu, A Oyo-Ita
Nov 5, 2009·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Giuseppe BorianiAngelo Branzi
Apr 29, 2011·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Giuseppe BorianiAngelo Auricchio
Apr 29, 2011·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Corinna SorensonMichael Drummond

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