Acute effects of beta-endorphin on cardiovascular function in patients with mild to moderate chronic heart failure

American Heart Journal
Domenico CozzolinoDario Giugliano

Abstract

Cardiomyocytes produce opioid peptides and receptors. beta-Endorphin is increased in the plasma of patients with congestive heart failure (CHF). We evaluated whether an intravenous infusion of beta-endorphin exerted any effect on cardiovascular function and on the neurohormonal milieu in patients with mild to moderate CHF. According to a double-blind, placebo-controlled design, 10 patients (5 men, age 46.9 +/- 8.2 years [mean +/- SD]) with CHF and New York Heart Association functional class II to III received, in random order, 1-hour intravenous infusion of beta-endorphin (500 microg/h) and, on a separate occasion, received placebo and underwent echocardiographic and laboratory measurements at baseline and during infusions. beta-Endorphin significantly increased left ventricular ejection fraction (LVEF) (P =.0001) and stroke volume (P =.0001), and reduced systemic vascular resistance (P =.031) in patients with CHF. These changes were paralleled by a significant increase in plasma levels of glucagon (P =.0001), GH (P =.0001), and IGF-1 (P =.0001), and a significant decrease in plasma levels of endothelin (P =.0001) and catecholamines (P =.01). No hemodynamic and neurohormonal changes were observed during the placebo study in any...Continue Reading

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Citations

Jul 26, 2005·Peptides·Richard J Bodnar, Gad E Klein
Oct 29, 2010·Journal of Cardiovascular Pharmacology·Reginald MatejecHeinz-Wilhelm Harbach
Feb 12, 2020·ESC Heart Failure·Elena Revuelta-LópezAntoni Bayés-Genís
Apr 21, 2020·International Journal of Endocrinology·Taisuke OkanoTakuya Watanabe
Apr 5, 2020·International Journal of Molecular Sciences·Naranjan S DhallaParamjit S Tappia
Jan 24, 2021·Cardiovascular Drugs and Therapy·Lukas DeheSascha Treskatsch
Apr 6, 2021·Internal and Emergency Medicine·Filipe M CunhaPatrícia Lourenço
Jun 3, 2021·International Journal of Molecular Sciences·Giuseppe PalmieroFerdinando Carlo Sasso
Jul 20, 2021·Frontiers in Medicine·Teresa SalvatoreFerdinando Carlo Sasso
Jul 20, 2021·Diabetes Research and Clinical Practice·Alfredo CaturanoFerdinando Carlo Sasso

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