Acute effects of blood pressure elevation on insulin clearance in normotensive healthy subjects

Hypertension
C J O'CallaghanW J Louis

Abstract

Reduced clearance of insulin from plasma contributes to the hyperinsulinemia associated with essential hypertension (EH); however, the association between impaired insulin clearance and EH remains unexplained. Whether elevated blood pressure (BP) affects insulin clearance is unknown; therefore, we used the hyperinsulinemic euglycemic clamp to determine the effects of BP elevation on insulin clearance and sensitivity in eight healthy volunteers. Placebo infusion increased mean BP by 2.6+/-1.6 mm Hg, which was significantly less than rises produced by phenylephrine, an alpha1-adrenoceptor agonist (+11+/-1.8 mmHg, P<.05), or by angiotensin II (+13+/-1.3 mmHg, P<.01). Although beta-adrenoceptor stimulation with isoproterenol did not change mean BP (+3.6 mm Hg, P=NS), it significantly increased systolic pressure (+23+/-2.8 mm Hg versus +2.3+/-4.6 mm Hg with placebo P<.01). Insulin secretion (ie, C-peptide concentrations) was not affected by any of the treatments; however, phenylephrine significantly reduced the metabolic clearance rate of insulin (MCRinsulin) (16.6+/-1.0 mL/kg per minute with placebo versus 13.6+/-0.7 mL/kg per minute with phenylephrine, P<.01) and thereby increased plasma insulin concentrations (66+/-5.1 microU/mL ...Continue Reading

References

Jun 1, 1992·American Journal of Hypertension·D GiuglianoF D'Onofrio
Jun 1, 1990·Diabetes Care·H RasmussenW S Zawalich
Sep 18, 1987·Science·O M Rosen
Oct 1, 1989·Hypertension·A P RocchiniM Gregory
May 1, 1986·The Journal of Clinical Endocrinology and Metabolism·Y KawaiI J Arinze
Aug 6, 1987·The New England Journal of Medicine·E FerranniniS Bevilacqua
Nov 1, 1967·The Journal of Clinical Investigation·G M ReavenJ W Farquhar
Mar 1, 1980·The Journal of Clinical Investigation·D C Deibert, R A DeFronzo
Mar 1, 1984·The Journal of Clinical Endocrinology and Metabolism·R P EatonD S Schade
Sep 1, 1994·Clinical and Experimental Hypertension : CHE·W H SheuM M Fuh
Jul 1, 1994·Diabetes/metabolism Reviews·M J CastilloP J Lefèbvre
Aug 1, 1993·The Journal of Clinical Investigation·T A BuchananW Hsueh

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