PMID: 8964766Mar 1, 1996Paper

Acute effects of caffeine ingestion at rest in humans with impaired epinephrine responses

Journal of Applied Physiology
M Van SoerenT E Graham

Abstract

Caffeine ingestion has been demonstrated to increase circulating epinephrine (Epi) and norepinephrine (NE), elevate free fatty acids (FFAs), and alter heart rate, blood pressure (BP), and ventilation in humans. Whether these physiological responses are a result of caffeine acting through direct stimulation of specific tissues via adenosine receptors or secondary to Epi increases is not known. In the present experiment, six tetraplegics (level of spinal cord lesions C4-C6) were tested at rest for 3 h to investigate the effects of 6 mg/kg caffeine in capsule form on subjects with impaired Epi responses. Ventilatory, cardiovascular, metabolic, and hormonal data were collected every 15-20 min after caffeine ingestion. There were no significant (P > 0.05) increases in plasma Epi after caffeine ingestion [0.19 +/- 0.04 (SE) nM (preingestion); 0.20 +/- 0.04 nM (80 min postingestion)] or in plasma NE [0.53 +/- 0.16 nM (preingestion); 0.49 +/- 0.09 nM (80 min postingestion; P > 0.05)]. However, significant increases were found in serum FFAs [0.53 +/- 0.08 nM (preingestion); 1.03 +/- 0.20 mM (40 min postingestion; P < 0.05] and in glycerol. These concentrations remained elevated throughout the experiment. BP increased in the first hour p...Continue Reading

Citations

Oct 7, 1998·Journal of Applied Physiology·M H Van Soeren, T E Graham
Oct 5, 2001·Sports Medicine·T E Graham
Oct 1, 1996·Journal of Applied Physiology·M JackmanT E Graham
Aug 4, 1998·Journal of Applied Physiology·E M KovacsF Brouns
Nov 25, 2000·Journal of Applied Physiology·T J HawkeM I Lindinger
Oct 29, 2000·Journal of Applied Physiology·F GreerT E Graham
Nov 20, 2002·Medicine and Science in Sports and Exercise·Mike DohertyMichael G Hughes
Jan 30, 2002·Diabetes Care·Gerben B KeijzersPaul Smits
Oct 28, 2006·Journal of Applied Physiology·D S BattramT E Graham
Sep 8, 1998·Journal of Applied Physiology·T E GrahamP Sathasivam
Jul 20, 2002·Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine·Ron BouchardJonathan D Geiger
Sep 27, 2016·Medicine and Science in Sports and Exercise·Terri Susan Graham-PaulsonVictoria Louise Goosey-Tolfrey
Apr 7, 2018·Critical Reviews in Food Science and Nutrition·João MonteiroBranca M Silva
Dec 18, 2008·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Terry E GrahamFarah S L Thong
Jul 15, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kristel DiepvensMargriet S Westerterp-Plantenga
Oct 7, 2006·The American Journal of Clinical Nutrition·James A GreenbergAllan Geliebter
Jul 30, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·João P MonteiroBranca M Silva
Feb 22, 2008·Journal of the International Society of Sports Nutrition·Vincent J DalboChad M Kerksick
Jan 5, 2010·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Adam S PtolemyMark Kellogg

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