PMID: 7018813Jul 1, 1981Paper

Acute effects of captopril on blood pressure and circulating hormone levels in salt-replete and depleted normal subjects and essential hypertensive patients

Clinical Science
J A MillarC I Johnston

Abstract

1. The acute effects of a single oral dose of captopril on blood pressure, pulse rate and circulating levels of angiotensin I (ANG I), angiotensin II (ANG II), renin, bradykinin and catecholamines were studied in three groups: eight normal subjects, six salt-depleted normal subjects and 16 patients with essential hypertension. 2. Captopril treatment did not cause any significant fall in supine blood pressure in salt-replete normal subjects or patients with untreated essential hypertension but was associated with a fall in mean blood pressure from 85 +/- 2 to 75 +/- 2 mmHg in salt-depleted normal subjects and from 131 +/- 7 to 117 +/- 5 mmHg in patients with essential hypertension treated with diuretics. There was no change in pulse rate in any group. 3. Hormonal responses to captopril were qualitatively similar in the three groups and consisted of significant falls in ANG II with corresponding increases in ANG I and plasma renin concentration. The changes in plasma renin concentration and ANG I were greater in salt-depleted normal subjects (mean values at 90 min were 1140% and 990% of basal levels respectively) than in salt-replete normal subjects (410%, 190%) and were blunted in patients with essential hypertension (140%, 120%...Continue Reading

Citations

Nov 1, 1990·Clinical and Experimental Pharmacology & Physiology·H SaitoT Inagami
Jan 1, 1987·Clinical and Experimental Hypertension. Part A, Theory and Practice·S SetoK Hashiba
Jan 1, 1984·Clinical and Experimental Hypertension. Part A, Theory and Practice·C I JohnstonL Arnolda
Jan 1, 1983·Clinical and Experimental Hypertension. Part A, Theory and Practice·K G HofbauerJ M Wood
Dec 1, 1982·British Journal of Clinical Pharmacology·A SturaniP Zucchelli
Jan 1, 1982·Clinical and Experimental Hypertension. Part A, Theory and Practice·A P NiarchosJ H Laragh
Aug 1, 1984·Australian and New Zealand Journal of Medicine·C I Johnston
Jun 1, 1984·British Journal of Clinical Pharmacology·P C RubinJ L Reid
Jan 1, 1984·British Journal of Clinical Pharmacology·C I JohnstonD Casley
Feb 18, 1998·Clinical Pharmacology and Therapeutics·M D GuazziM Alimento
Jan 1, 1982·Clinical and Experimental Hypertension. Part A, Theory and Practice·J A Millar
Oct 1, 1986·British Journal of Clinical Pharmacology·R H BeckerM J Brown
Apr 1, 1986·European Journal of Clinical Investigation·O B PaulsonJ Godtfredsen
Oct 1, 1981·European Journal of Clinical Investigation·J Giese, S Rasmussen
May 1, 1983·Clinical and Experimental Pharmacology & Physiology·J A MillarJ L Reid
Jan 1, 1982·Clinical and Experimental Hypertension. Part A, Theory and Practice·W OelkersM Meyland
Dec 1, 1990·Journal of Clinical Pharmacy and Therapeutics·D G BeeversJ F Potter

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