Acute effects of complete blood exchange with ultra-purified hemoglobin solution or hydroxyethyl starch on liver and kidney in the animal model

Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS
T StandlD E Lorke

Abstract

The present animal study investigates the influence of an acute and almost complete isovolaemic haemodilution with a new ultrapurified polymerized bovine haemoglobin (UPBH) on hepatic and renal function and histology in comparison to hydroxyethylstarch (HES). Eighteen anaesthetized dogs underwent progressive isovolaemic haemodilution with either HES (group 1) or UPBH (group 2) to haematocrit target levels of 15, 10 and < 5%. Haemodynamics, arterial and mixed-venous blood gases and blood chemistry were determined at each measurepoint. With a haematocrit value < 5%, biopsies were taken from the liver and kidneys and prepared for light and electron microscopic analysis. One dog without haemodilution figured as control animal. Statistical analysis was performed using ANOVA, with p < 0.05 considered significant. In group 1, the cardiac output was increased in parallel to a decreasing vascular resistance, while in group 2 haemodynamic parameters remained unchanged. In group 1, avDO2 and final DO2 and VO2 were decreased. In contrast, avDO2 and oxygen extraction ratio were increased, while VO2 remained stable under decreasing DO2 in group 2. In both groups, coagulation values and blood chemistry showed dilution dependent changes. Collo...Continue Reading

Citations

Jun 6, 2000·Advanced Drug Delivery Reviews·D R Spahn
Nov 30, 2000·Critical Care : the Official Journal of the Critical Care Forum·J F Baron
Nov 22, 2013·Intensive Care Medicine·Christian J Wiedermann, Michael Joannidis
Jan 26, 2007·British Journal of Anaesthesia·Y SakrJ-L Vincent
Oct 28, 2005·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Marc FreitagJochen Schulte Am Esch
Apr 16, 2019·Journal of Veterinary Emergency and Critical Care·Sarah M SchmidLesley G King
Jun 23, 2019·Journal of Veterinary Emergency and Critical Care·Gaby van Galen, Gayle Hallowell
Feb 7, 2015·Journal of Veterinary Emergency and Critical Care·Katja N AdamikNadine Regenscheit
Feb 26, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Michael DickenmannMichael J Mihatsch

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