PMID: 9539070Apr 16, 1998Paper

Acute effects of continuous rotational therapy on ventilation-perfusion inequality in lung injury

Intensive Care Medicine
T BeinG Hedenstierna

Abstract

To investigate ventilation-perfusion (VA/Q) relationships, during continuous axial rotation and in the supine position, in patients with acute lung injury (ALI) using the multiple inert gas elimination technique. Prospective investigation. Eighteen-bed intensive care unit in a university hospital. Ten patients with ALI (PaO2/FIO2 ratio < 300 mm Hg) were mechanically ventilated in a pressure controlled mode and placed on a kinetic treatment table. Distributions of VA/Q were determined 1) during rotation (after a period of 20 min) and 2) after a resting period of 20 min in the supine position. During axial rotation, intrapulmonary shunt (19.1 +/- 15% of cardiac output) was significantly reduced in comparison with when in the supine position (23 +/- 14%, p < 0.05), areas with "low" VA/Q were not affected by the positioning maneuver. General VA/Q mismatch (logarithmic distribution of pulmonary blood flow) was decreased during rotation (0.87 +/- 0.37) in comparison with when the patient was in the supine position (0.93 +/- 0.37, p < 0.05). Arterial oxygenation was significantly improved during continuous rotation (PaO2/FIO2 = 217 +/- 137 mm Hg) as compared with in the supine position (PaO2/FIO2 = 174 +/- 82 mm Hg, p < 0.05). The pos...Continue Reading

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Citations

Oct 23, 2012·Medizinische Klinik, Intensivmedizin und Notfallmedizin·T Bein
Jan 11, 2001·Acta Anaesthesiologica Scandinavica·P Neumann, G Hedenstierna
Nov 30, 2000·Journal of Advanced Nursing·A N BreiburgJ D Pierce
Oct 1, 2009·Critical Care Medicine·Thomas StaudingerGottfried J Locker
Feb 14, 2006·Nursing in Critical Care·Anna Marklew
Apr 12, 2001·Critical Care : the Official Journal of the Critical Care Forum·K DavisR D Branson
Jul 30, 2009·AACN Advanced Critical Care·Karen L Johnson, Tim Meyenburg
Jun 7, 2003·Anaesthesia·N MalarkkanA B Lumb
Jan 11, 2012·Nursing in Critical Care·Stephen Wanless, Matthew Aldridge
Jan 31, 2008·Journal of Intensive Care Medicine·Kevin M SchusterErik S Barquist
Jan 25, 2005·Journal of Intensive Care Medicine·Eric A J HosteFrancis A Colardyn
Oct 23, 2012·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Valerie G SamsBrian J Daley
May 26, 2017·The Journal of Trauma and Acute Care Surgery·Mark SchierenJérôme Defosse

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