Acute effects of D-fenfluramine on simultaneous measures of aggressive escape and impulsive responses of adult males with and without a history of conduct disorder

Psychopharmacology
Don R Cherek, Scott D Lane

Abstract

The role of serotonin in human aggression was evaluated by administering D-fenfluramine and comparing the effects on laboratory measures of aggression, escape and impulsivity among subjects with and without a history of conduct disorder. Ten male subjects with a history of criminal behavior participated in experimental sessions that measured aggressive and impulsive responses. Five subjects had a history of childhood conduct disorder (CD+) and five control subjects did not. Aggression was measured using the Point Subtraction Aggression Paradigm (PSAP), which provides subjects with an aggressive, escape and monetary reinforced response options. Impulsive responses were measured using a paradigm that gives subjects choices between small rewards after short delays versus larger rewards after long delays. Acute doses (0.1, 0.2 and 0.4 mg/kg) of D-fenfluramine produced significant decreases in aggressive responses in CD+ subjects and large decreases in escape responses for CD+ subjects and smaller decreases for control subjects. Impulsive responses were decreased slightly and monetary reinforced responses were not changed in either group. Decreases in aggressive responses were not selective, since escape responses were also decrease...Continue Reading

Citations

Jan 6, 2007·Psychopharmacology·Jesse Dallery, Bethany R Raiff
Apr 22, 2010·Psychopharmacology·Joshua L GowinScott D Lane
May 18, 2013·Psychopharmacology·Jakob NäslundElias Eriksson
May 9, 2009·Psychological Science·Mitchell E BermanEmil F Coccaro
Nov 19, 2008·BMC Neuroscience·Craig F FerrisNeal G Simon
Sep 30, 2014·Drug and Alcohol Dependence·Allison N Kurti, Jesse Dallery
Mar 20, 2009·Psychoneuroendocrinology·Vinicius Guandalini GuapoCristina Marta Del-Ben
Nov 25, 2003·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Donald M DoughertyAlan C Swann
Feb 3, 2009·Alcoholism, Clinical and Experimental Research·Michael S McCloskeyEmil F Coccaro
Jul 27, 2007·Aggressive Behavior·Sylvain O NouvionLori M Lieving
Jul 11, 2006·Progress in Neuro-psychopharmacology & Biological Psychiatry·Jiansong ZhouYehua Sun
Dec 6, 2005·European Journal of Pharmacology·Rosa M M de AlmeidaKlaus A Miczek
May 1, 2012·Neuroscience·J W Dalley, J P Roiser
Nov 12, 2016·Neuroscience and Biobehavioral Reviews·Floriana MogaveroJeffrey C Glennon
Feb 2, 2013·Psychopharmacology·Joshua L GowinScott D Lane
Mar 30, 2007·Violence and Victims·Beatrice A GolombJoel Dimsdale
Sep 1, 2017·Journal of Psychopharmacology·R L Carhart-Harris, D J Nutt
Aug 5, 2015·Behavioural Pharmacology·Joseph L AlcornScott D Lane

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