Acute effects of dietary fat on inflammatory markers and gene expression in first-degree relatives of type 2 diabetes patients.

The Review of Diabetic Studies : RDS
Anna PietraszekKjeld Hermansen

Abstract

Subjects with type 2 diabetes (T2D) and their relatives (REL) carry an increased risk of cardiovascular disease (CVD). Low-grade inflammation, an independent risk factor for CVD, is modifiable by diet. Subjects with T2D show elevated postprandial inflammatory responses to fat-rich meals, while information on postprandial inflammation in REL is sparse. To clarify whether medium-chain saturated fatty acids (SFA) and monounsaturated fatty acids (MUFA) have differential acute effects on low-grade inflammation in REL compared to controls (CON). In randomized order, 17 REL and 17 CON ingested two fat-rich meals, with 72 energy percent from MUFA and 79 energy percent from mainly medium-chain SFA, respectively. Plasma high sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), adiponectin, and leptin were measured at baseline, 15 min, 60 min, and 240 min postprandially. Muscle and adipose tissue biopsies were taken at baseline and 210 min after the test meal, and expression of selected genes was analyzed. Plasma IL-6 increased (p < 0.001) without difference between REL and CON and between the meals, whereas plasma adiponectin and plasma hs-CRP were unchanged during the 240 min observation period. Plasma leptin decreased slightl...Continue Reading

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Citations

Jul 13, 2013·Molecular Nutrition & Food Research·Mohammed Herieka, Clett Erridge
Oct 31, 2015·European Journal of Nutrition·Rebecca L TraversDylan Thompson
Jan 12, 2017·São Paulo Medical Journal = Revista Paulista De Medicina·Daniela Mayumi RochaHelen Hermana Hermsdorff
May 5, 2018·Medicine and Science in Sports and Exercise·Yung-Chih ChenDylan Thompson
Feb 18, 2020·The Proceedings of the Nutrition Society·R Dewhurst-TriggO Markey
Oct 3, 2020·Nutrients·Jun Wern YauAmutha Ramadas
Oct 28, 2017·Nutrition & Metabolism·Dominique HermierFrançois Mariotti

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