Acute effects of distal pancreatectomy on portal and peripheral blood insulin concentrations in patients undergoing total gastrectomy

Surgery Today
J HayakawaY Usuda


The influence of distal pancreatectomy on portal and peripheral blood immunoreactive insulin (IRI) and immunoreactive glucagon (IRG) concentrations was evaluated in patients undergoing total gastrectomy. There were 22 patients studied, 12 of whom did not undergo distal pancreatectomy (group 1), and 10 who did (group 2). In group 2, the increase in portal blood IRI concentrations after a glucose infusion of 25 g over 30 min was suppressed, and reelevation of the portal blood IRG concentration after the glucose-induced depression was inhibited compared to group 1. In contrast, the peripheral blood IRI concentration did not reflect these changes in the portal blood IRI concentration. The rise in the arterial ketone body ratio (AKBR) and the fall in the total ketone body concentration after glucose infusion were also attenuated after distal pancreatectomy in group 2. These findings suggest that distal pancreatectomy has an immediate suppressive effect on the pancreatic secretion of insulin and glucagon, and might disturb metabolism in the liver.


Sep 1, 1978·Acta diabetologica latina·K KimuraT Tobe
Jan 1, 1977·Annals of Surgery·T YamadaI Honjo
Sep 30, 1987·Clinica Chimica Acta; International Journal of Clinical Chemistry·S UnoK Ozawa
May 1, 1971·Diabetes·W G Blackard, N C Nelson

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Feb 8, 2002·Zhonghua wai ke za zhi [Chinese journal of surgery]·Z KeJ Hua
Apr 28, 1999·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·A Cuschieri

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