PMID: 11927386Apr 3, 2002Paper

Acute effects of fatty acids on insulin secretion from rat and human islets of Langerhans

The Journal of Endocrinology
Clarice GravenaStephen J H Ashcroft

Abstract

Fatty acids have both stimulatory and inhibitory effects on insulin secretion. Long-term exposure to fatty acids results in impaired insulin secretion whilst acute exposure has generally been found to enhance insulin release. However, there are conflicting data in the literature as to the relative efficacy of various fatty acids and on the glucose dependency of the stimulatory effect. Moreover, there is little information on the responses of human islets in vitro to fatty acids. We have therefore studied the acute effects of a range of fatty acids on insulin secretion from rat and human islets of Langerhans at different glucose concentrations. Fatty acids (0.5 mM) acutely stimulated insulin release from rat islets of Langerhans in static incubations in a glucose-dependent manner. The greatest effect was seen at high glucose concentration (16.7 mM) and little or no response was elicited at 3.3 or 8.7 mM glucose. Long-chain fatty acids (palmitate and stearate) were more effective than medium-chain (octanoate). Saturated fatty acids (palmitate, stearate) were more effective than unsaturated (palmitoleate, linoleate, elaidate). Stimulation of insulin secretion by fatty acids was also studied in perifused rat islets. No effects were...Continue Reading

Citations

Nov 16, 2013·Archives of Pharmacal Research·Yun Jung ChoiJu-Yeun Lee
May 2, 2013·Trends in Endocrinology and Metabolism : TEM·Arturo D Mancini, Vincent Poitout
Jan 5, 2005·Diabetes Technology & Therapeutics·S Del Prato, P Marchetti
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Apr 2, 2011·Molecular Human Reproduction·Romina NovembriFelice Petraglia
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