PMID: 17269596Feb 3, 2007Paper

Acute effects of hemodialysis on salivary flow rate and composition

Clinical Nephrology
C P BotsA V Nieuw Amerongen


To evaluate acute effects of hemodialysis (HD) on the salivary flow rate, pH and biochemical composition before, during and after completion of a dialysis session. Unstimulated whole saliva (UWS) and chewing-stimulated whole saliva (CH-SWS) were collected in 94 HD patients. Salivary flow rate, pH, concentrations of total protein, albumin, cystatin C, secretory immunoglobulin A (S-IgA) and of sodium, potassium and urea were measured. HD had an acute stimulating effect on the salivary flow rate (UWSbefore = 0.30+/-0.22 ml/min, UWSduring = 0.39+/-0.25 ml/min, p < 0.005). The mean pH of UWS showed a small but significant increase during HD mainly due to an increased watery secretion from the salivary glands. The salivary biochemical constituents changed markedly, but no significant difference in output was found. The electrolyte concentration did not change significantly during dialysis. The level of urea in CH-SWS declined to 40% (Ureabefore = 25.+/-6.4 mmol/l, Ureaduring = 15.3+/-4.5 mmol/1). This study shows that HD has significant acute effects on both salivary secretion rate and protein concentrations in saliva. We conclude that the observed changes in salivary concentrations and proteins are mainly due to an increased watery ...Continue Reading


Jan 18, 2012·Nature Reviews. Nephrology·Maurizio Bossola, Luigi Tazza
Dec 4, 2015·Clinica Chimica Acta; International Journal of Clinical Chemistry·Peter CelecPeter Boor
Nov 22, 2011·Hemodialysis International·Dirk ZiebolzRainer F Mausberg
Jul 22, 2014·Artificial Organs·Paulo Leonardo Ponte MarquesMaria Vieira de Lima Saintrain
May 28, 2015·European Journal of Clinical Nutrition·Karen Joy Manley
Dec 16, 2016·British Journal of Biomedical Science·J LimeresP Diz
Jul 26, 2014·British Dental Journal·C P BotsH S Brand
Nov 26, 2008·Scandinavian Journal of Clinical and Laboratory Investigation·Estela M L CardosoLiliana N Contreras
Mar 1, 2013·Journal of Breath Research·F M SchmidtL Halonen
Aug 1, 2014·Journal of Breath Research·W ChenL Halonen
May 23, 2019·Seminars in Dialysis·Maurizio Bossola
Jan 2, 2019·Journal of Medical Biochemistry·Medine AlpdemirDoğan Yücel

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