Acute effects of lipid apheresis on human serum lipidome

Atherosclerosis. Supplements
Sergey TselminJuergen Graessler

Abstract

Lipid apheresis is an efficient method for reducing cholesterol and triglyceride serum levels, but its effect on other lipid species has not been investigated. This study explored the effect of LDL apheresis on the serum lipidome in hyperlipidemic patients with cardiovascular complications. Lipid analysis was performed before and immediately after a single apheresis procedure in serum samples of six patients treated with different apheresis methods. Conventional lipid parameters (TC, LDL-C, HDL-C, TG) were determined by standard enzymatic methods. Phosphatidylcholines (PC), sphingomyelins (SM), phosphatidylethanolamines (PE), PE-based plasmalogens (PE_pl), lysophosphatidylcholines (LPC), ceramides (Cer), free cholesterol (FC) and cholesterol ester (CE) were detected with electrospray ionization tandem mass spectrometry. LDL apheresis induced a mean reduction of LDL-C by 68% and of HDL-C by 14%, respectively. CE, FC, SM, and Cer revealed an apheresis-induced decrease of about 47%, which was not statistically different from LDL-C reduction. In contrast, the decline of PC (31%), LPC (26%), PE (2%), and PE_pl (37%) after apheresis was significantly lower in comparison to LDL-C reduction, but not statistically different from HDL-C d...Continue Reading

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