Acute effects of parathyroid hormone on vitamin D metabolism in patients with the bone loss of aging

The Journal of Clinical Endocrinology and Metabolism
O H SørensenA W Norman

Abstract

This study was carried out to evaluate the effects of an iv injection of parathyroid extract on serum levels of 1,25-dihydroxyvitamin D [1,25-(OH)2D3] in elderly osteopenic patients and age-matched nonosteopenic controls. Serum concentrations of 1,25-(OH)2D were reduced in elderly osteopenic subjects (mean +/- SEM, 20 +/- 3 pg/ml) compared with values in age-matched nonosteopenic controls (35 +/- 3 pg/ml), whereas no differences were found in serum 24,25-dihydroxyvitamin D levels (1.5 +/- 0.3 and 2.2 +/- 0.5 ng/ml, respectively). An iv injection of parathyroid extract was followed by a significant increase in serum 1,25-(OH)2D levels in both osteopenic patients (16 +/- 6 pg/ml) and controls (15 +/- 5 pg/ml). The mean 4-h increases in serum 1,25-(OH)2D of 11-18 pg/ml were not significantly different in the two groups. The results indicate that the reduced 1,25-(OH)2D concentrations in the osteopenic patients are secondary to changes in factors that normally stimulate this enzyme system.

Citations

Mar 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J FriedlanderM J Favus
Mar 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Y F MaN Yamamoto
Jan 1, 1984·Calcified Tissue International·C Christiansen, P Rødbro
Jul 1, 1997·Baillière's Clinical Endocrinology and Metabolism·R BouillonS Boonen
Jul 5, 1984·The New England Journal of Medicine·L V Avioli, J G Haddad
Jun 1, 1984·The Journal of Clinical Investigation·K S TsaiB L Riggs
Jul 1, 1995·Journal of the American Geriatrics Society·F M Gloth, J D Tobin
Feb 6, 1992·The New England Journal of Medicine·M W TilyardS Dovey
Jul 17, 1998·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·W D FraserI T Boyle
Jan 1, 1996·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J M Quesada-GómezR Bouillon
Feb 2, 1989·The New England Journal of Medicine·S J SilverbergJ P Bilezikian
Dec 1, 1990·Journal of the American Geriatrics Society·R L PierronT Stewart
Feb 1, 1984·The American Journal of Physiology·Y Tanaka, H F DeLuca
Apr 1, 1990·Metabolism: Clinical and Experimental·B L Riggs

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