Acute effects of progesterone and the antiprogestin RU 486 on gonadotropin secretion in the follicular phase of the menstrual cycle

The Journal of Clinical Endocrinology and Metabolism
J M PermezelI D Cooke

Abstract

Considerable controversy still exists concerning the role of progesterone in the initiation of the midcycle gonadotropin surge in humans. We, therefore, carried out a prospective randomized study to determine the potential of progesterone to initiate a gonadotropin surge and the acute effects of a potent progesterone antagonist (RU 486) on follicular phase gonadotropin secretion in normal women. The women underwent frequent blood sampling for 4 in the midfollicular (day 6) or late follicular phase (day 10). They then received either progesterone (10 mg, im) or RU 486 (10 or 100 mg, orally), and blood sampling was continued for an additional 8 h. Four women received each of the drug regimens in the early follicular phase, and four received each regimen in the late follicular phase. Two additional women were studied as control subjects at each stage of the cycle. Progesterone administration in the mid- and late follicular phases resulted in an acute increase in plasma LH and FSH concentrations, and the increases correlated with the base line plasma estradiol concentrations (P less than 0.05). In contrast to progesterone, the women who received RU 486 in the mid- and late follicular phases had a reduction in plasma LH and FSH conc...Continue Reading

Citations

Dec 31, 2003·Contraception·Kristina Gemzell-DanielssonLena Marions
Jan 7, 1998·Fertility and Sterility·D K Mahajan, S N London
Aug 5, 1993·The New England Journal of Medicine·I M Spitz, C W Bardin
Jan 1, 1997·Annual Review of Medicine·F CadepondE E Baulieu
Nov 1, 1993·Contraception·I M Spitz, C W Bardin
Jun 14, 2014·Reproductive Biomedicine Online·Charlotte SonigoJean-Noel Hugues
Feb 1, 1990·The Australian & New Zealand Journal of Obstetrics & Gynaecology·M Permezel
Feb 1, 1993·Annals of Medicine·O Heikinheimo, R Kekkonen
Mar 11, 2020·Frontiers in Cell and Developmental Biology·Hongmei ZhuMingxing Ding
Jul 28, 2018·Journal of Assisted Reproduction and Genetics·Apostolos KaponisGeorge Decavalas

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