Acute effects of progesterone on glucose metabolism in rat adipocytes: are they modulated by endogenous adenosine?

Metabolism: Clinical and Experimental
M T Sutter-Dub, P Cordoba

Abstract

Progesterone rapidly inhibits glucose oxidation of isolated rat adipocytes. Because this inhibition is triggered by endogenous adenosine, the present study was designed to examine the effect of the steroid on cyclic adenosine monophosphate (cAMP) accumulation, its relation to lipolysis, and the possible participation of adenosine. The results strongly indicate that physiological concentrations of progesterone increase the release of adenosine by isolated adipocytes, with maximal release at the end of a 20-minute incubation. Progesterone decreased both cAMP levels and lipolysis in quiescent adipocytes or in adipocytes stimulated by isoproterenol. The increase of endogenous adenosine may explain the decline of cAMP and glycerol levels observed with progesterone. The effects of the steroid on lipolysis disappeared when adenosine was hydrolyzed by adenosine deaminase (ADA). On the other hand, in the absence of endogenous adenosine, the effect of progesterone on the cAMP level was decreased only in isoproterenol-stimulated cells. The inhibitory effects of progesterone on cAMP and glycerol production seem not to be related directly to the adenosine A1 receptor, for selective A1 receptor antagonists (8-cyclopentyl-1,3-dipropylxanthine...Continue Reading

References

Jun 21, 1979·Biochimica Et Biophysica Acta·J N Fain
Dec 1, 1991·Canadian Journal of Physiology and Pharmacology·P CordobaM T Sutter-Dub
Jan 1, 1986·Progress in Neurobiology·J A Ribeiro, A M Sebastião
Aug 1, 1987·Naunyn-Schmiedeberg's Archives of Pharmacology·M J LohseR A Olsson
Mar 1, 1987·The American Journal of Physiology·M L ElksM Vaughan
May 15, 1987·Analytical Biochemistry·H KatherW Waas
Mar 1, 1966·Clinica Chimica Acta; International Journal of Clinical Chemistry·S Laurell, G Tibbling
Jan 1, 1974·Naunyn-Schmiedeberg's Archives of Pharmacology·U Schwabe, R Ebert
Jun 1, 1981·FEBS Letters·T S TeoE H Wong
Nov 25, 1982·Nucleic Acids Research·R J Wilkins
Apr 1, 1981·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·M T Sutter-Dub, B Dazey
Aug 1, 1981·The Journal of Endocrinology·D ShirlingJ D Baird
Dec 1, 1980·Acta Endocrinologica·F M HansenJ H Nielsen
Sep 10, 1995·Archives of Biochemistry and Biophysics·V C ManganielloE Degerman

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Citations

Feb 6, 2004·Journal of Neurochemistry·David LeónMairena Martín
Jul 5, 2003·Physiological Reviews·Ralf M LoselMartin Wehling
Oct 8, 1999·Clinica Chimica Acta; International Journal of Clinical Chemistry·J SalehK Cianflone

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