Acute effects of Rho-kinase inhibitor fasudil on pulmonary arterial hypertension in patients with congenital heart defects

Circulation Journal : Official Journal of the Japanese Circulation Society
Jia-wang XiaoLi-li Meng

Abstract

We investigated the acute vasodilator effects of i.v. fasudil, a specific Rho-kinase inhibitor, on pulmonary circulation in patients with congenital heart defects (CHD) and severe pulmonary arterial hypertension (PAH). Thirty-five patients (34.23±12.10 years old) with CHD and severe PAH were consecutively enrolled. All patients underwent heart catheterization. At baseline and 30 min after initiation of i.v. fasudil, the following hemodynamic parameters were measured and calculated: right atrial pressure, pulmonary and systemic artery pressure (PAP and SAP), pulmonary and systemic vascular resistance, pulmonary-to-systemic blood pressure ratio (Pp/Ps), pulmonary-to-systemic blood flow ratio (Qp/Qs), cardiac index (CI) and artery oxygen saturation (SaO2). After fasudil treatment, marked decrease in mean PAP (mPAP), pulmonary vascular resistance (PVR), total pulmonary resistance, pulmonary-to-systemic vascular resistance ratio (Rp/Rs) and mean Pp/Ps (mPp/Ps) was found, while Qp/Qs increased significantly without affecting CI and SAP. mPAP, PVR, Rp/Rs and Qp/Qs tended to be improved more significantly in the post-tricuspid shunt group compared with the pre-tricuspid shunt group. Fasudil was well tolerated in patients with CHD and s...Continue Reading

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Citations

Nov 17, 2015·Circulation Journal : Official Journal of the Japanese Circulation Society·Yasufumi KijimaHiroshi Ito
May 1, 2015·Circulation Journal : Official Journal of the Japanese Circulation Society·Keiichi Odagiri, Hiroshi Watanabe
Jun 3, 2016·Circulation Journal : Official Journal of the Japanese Circulation Society·Toru Shimizu, James K Liao
Feb 2, 2018·American Journal of Physiology. Lung Cellular and Molecular Physiology·Matthew K HensleyYen-Chun Lai
Dec 20, 2017·Frontiers in Pharmacology·Allan K N AlencarGisele Zapata-Sudo
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Feb 20, 2020·Expert Opinion on Drug Delivery·Ali KeshavarzFakhrul Ahsan
Aug 19, 2018·Molecular Psychiatry·Megan E FoxMary Kay Lobo
Apr 11, 2019·Molecular Psychiatry·Megan E Fox, Mary Kay Lobo
Nov 3, 2016·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Takahiro HorinouchiSoichi Miwa
May 28, 2019·Antioxidants & Redox Signaling·Pratap Karki, Konstantin G Birukov
Jul 4, 2021·Current Opinion in Pharmacology·Md Khadem AliEdda Spiekerkoetter

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