Acute effects of simultaneous intraperitoneal infusion of glucose and amino acids

Kidney International
A CanepaF Perfumo

Abstract

The feasibility of simultaneously infusing glucose and amino acid (AA)-based peritoneal dialysis solutions was tested to determine whether peritoneal dialysis patients could achieve an adequate nonprotein calorie/nitrogen ratio while preventing a marked increase in blood urea nitrogen (BUN), which is usually seen if the AAs are administered without glucose. An automatic peritoneal dialysis cycler was used to infuse glucose and AA solutions (3:1) simultaneously during the night. Eight infusions of 1000 mL m2 of body surface area (BSA), with a 60 minute dwell time, were performed in 10 children on peritoneal dialysis. The dialytic effluent was analyzed at every exchange and totaled at eight hours to evaluate volume, glucose, and AA concentration. Blood samples for plasma, glucose, insulin, and free AA determination were drawn at the beginning of automated peritoneal dialysis (APD) session and at each instillation of peritoneal dialysate. The mean glucose absorption was 33.7 +/- 10.0% and the AA absorption was 55.2 +/- 13.2% of the infused amount, and the ratio of nonprotein calorie (derived from glucose) to nitrogen (derived from AA) was 115.4:1. The insulin levels returned to normal only three hours after the beginning of APD. T...Continue Reading

References

Jun 24, 1976·The New England Journal of Medicine·G R GreenbergK N Jeejeebhoy
Mar 1, 1991·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·A CanepaR Gusmano
Jan 1, 1989·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·G A YoungA M Brownjohn
May 1, 1989·Kidney International·M BrunoF Linari
May 1, 1989·Kidney International·B LindholmJ Bergström
Nov 1, 1982·The Journal of Clinical Investigation·N N AbumradW W Lacy
May 1, 1983·The Journal of Pediatrics·C J StefanidisJ W Balfe
Oct 1, 1983·The American Journal of Clinical Nutrition·I B SaluskyJ D Kopple
Jul 1, 1983·Kidney International·C M TaylorJ P Bonjour
Apr 1, 1981·Kidney International·G P GrodsteinJ W Coburn
Apr 1, 1995·Kidney International·J D KoppleD M Bier
Jan 1, 1995·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·T B Drüeke
Nov 1, 1996·Journal of the American Society of Nephrology : JASN·B A WaradyE C Kohaut

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Citations

Jan 12, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Lesley Rees, Vanessa Shaw
Jun 4, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Enrico VerrinaFrancesco Perfumo
Mar 31, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Claus Peter SchmittUNKNOWN European Pediatric Dialysis Working Group
Sep 17, 2002·Kidney International. Supplement·Ram GokalSalim Mujais
May 3, 2008·Kidney International. Supplement·A CanepaF Perfumo
Aug 21, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Hoey Lan TjiongMarien W Fieren
Aug 8, 2021·International Journal of Molecular Sciences·Mario BonominiGiovanni Gambaro
Aug 31, 2021·Frontiers in Nutrition·Giacomo GaribottoGiuliano Brunori

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