Acute effects of the superoxide dismutase mimetic tempol on split kidney function in two-kidney one-clip hypertensive rats

Journal of Hypertension
Gregor S GuronHans Herlitz

Abstract

To investigate the acute effects of the superoxide dismutase mimetic 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (tempol) on split kidney function, and renal haemodynamics, in two-kidney, one-clip (2K1C) hypertensive rats. Three weeks after clipping, or the sham procedure, the effects of intravenous tempol (200 micromol/kg per h) were evaluated on thiobutabarbital anaesthetized Sprague-Dawley rats. Mean arterial pressure (MAP; 152 +/- 3 versus 122 +/- 3 mmHg, P < 0.001), plasma renin activity (28.7 +/- 3.0 versus 9.5 +/- 0.6 ng/ml per h, P < 0.001) and urinary 8-iso-prostaglandin F2alpha excretion (124 +/- 4 versus 92 +/- 10 pmol/24 h, P = 0.003) were significantly elevated in 2K1C rats compared with sham. Tempol reduced MAP by 15 +/- 1% compared with baseline (P < 0.001) in 2K1C rats. In clipped kidneys, tempol increased the glomerular filtration rate (GFR; +50 +/- 15% from baseline) and the effective renal plasma flow (ERPF; +37 +/- 13%, from baseline), and reduced renal vascular resistance (RVR; -32 +/- 6% from baseline) compared with saline-treated controls (P < 0.05). In non-clipped kidneys, tempol reduced RVR (-24 +/- 5% from baseline) compared with saline-treated controls (P = 0.001). In sham-operated rats, tempol pro...Continue Reading

References

Jul 15, 1999·Journal of the American Society of Nephrology : JASN·G GuronP Friberg
Sep 1, 2000·Regulatory Peptides·K K Griendling, M Ushio-Fukai
Aug 24, 2001·Journal of the American Society of Nephrology : JASN·Thomas K A WieremaPeter W DE Leeuw
Mar 8, 2002·Hypertension·L Gabriel NavarHiroyuki Kobori
Mar 9, 2002·Current Hypertension Reports·Christopher S Wilcox
Jun 21, 2002·The New England Journal of Medicine·Yukihito HigashiKazuaki Chayama
Aug 28, 2002·Circulation·Alejandro R ChadeLilach O Lerman
Oct 10, 2002·American Journal of Physiology. Renal Physiology·Pablo A Ortiz, Jeffrey L Garvin
Nov 22, 2002·Journal of the American Society of Nephrology : JASN·Noritaka KawadaChristopher S Wilcox
Dec 11, 2002·Kidney International·William J WelchChristopher S Wilcox
Mar 1, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Tina ChabrashviliChristopher S Wilcox
Mar 11, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jane F Reckelhoff, J Carlos Romero
Aug 20, 2003·Hypertension·Alejandro R ChadeLilach O Lerman
Jan 15, 2004·American Journal of Physiology. Renal Physiology·Alejandro R ChadeLilach O Lerman
Jun 18, 2004·Kidney International·Ruisheng LiuOscar A Carretero
Jun 16, 2005·Kidney International·William J WelchChristopher S Wilcox

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Citations

Dec 30, 2008·Pharmacological Reviews·Christopher S Wilcox, Adam Pearlman
Mar 10, 2009·Pharmacology & Therapeutics·Ulf SimonsenNiels Henrik Buus
Aug 5, 2016·Chemical & Pharmaceutical Bulletin·Yan SunMinghua Zhang
Feb 21, 2009·American Journal of Hypertension·Elizabeth B Oliveira-SalesRuy R Campos
Jan 24, 2018·Clinical and Experimental Hypertension : CHE·Douglas Vq NunesDayane T Ognibene
Sep 4, 2014·Journal of the American Society of Nephrology : JASN·Lina NordquistFredrik Palm
May 28, 2010·American Journal of Physiology. Renal Physiology·Hua LuXin J Zhou
May 1, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Mattias CarlströmA Erik G Persson

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