Acute effects of thymoquinone on the pregnant rat and embryo-fetal development

Drug and Chemical Toxicology
M M AbukhaderHisham Y Al-Matubsi

Abstract

The effect of a single intraperitoneal (i.p.) injection of thymoquinone (TQ) on the pregnant rat and embryo-fetal development was investigated. Pregnant female Wistar rats received 15, 35, and 50 mg/kg body weight of TQ i.p. on day 11 or 14 of gestation, and on day 18 of gestation they were sacrificed and laparotomized. Results showed that TQ induces maternal and embryonic toxicities in a dose- and time-dependent manner. With a dose of 50 mg/kg, treated rats experienced a significant decrease in maternal body weight and complete fetal resorption when the dose was given on day 11 of gestation. On the other hand, 46.2% of implants were resorbed and the viable fetuses showed no TQ-related malformations when the dose was given on day 14 of gestation. At a lower TQ dose of 35 mg/kg, maternal and embryonic toxicities were observed only when it was given on day 11 of gestation. The dose of 15 mg/kg was considered to be a dose with no observed adverse effect level for maternal and embryo-fetal toxicities when it was given day 11 or 14 of gestation. Based on the results of this study, TQ, at doses of 50 and 35 mg/kg, has a potentially disruptive effect on embryonic development during the second trimester of rat pregnancy.

References

Dec 1, 1979·Journal of Cutaneous Pathology·J R CannonM A Everett
Jan 1, 1978·British Journal of Obstetrics and Gynaecology·C Williams, T M Coltart
Aug 1, 1975·Diabetologia·L Aerts, F A Assche
Apr 1, 1992·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·W J KrasavageS J Murphy
Aug 1, 1990·American Journal of Obstetrics and Gynecology·I W Smoak, T W Sadler
Jul 1, 1987·American Journal of Obstetrics and Gynecology·T W Sadler, E S Hunter
Feb 5, 1968·Annals of the New York Academy of Sciences·J B Josimovich, D H Mintz
Sep 1, 1983·Proceedings of the Society for Experimental Biology and Medicine·P A Tonkowicz, J L Voogt
Nov 1, 1994·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·H S AhujaZ F Zakeri
Jun 1, 1997·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·R L Sorenson, T C Brelje
Aug 26, 1998·The American Journal of Gastroenterology·L Gianfrate, L Ferraris
Nov 7, 1998·Molecular and Cellular Endocrinology·Y KandaS Handwerger
Mar 22, 2000·Chemical Research in Toxicology·J L BoltonT J Monks
Apr 25, 2000·Journal of Pediatric Endocrinology & Metabolism : JPEM·S Handwerger, M Freemark
Aug 5, 2000·Phytotherapy Research : PTR·M Burits, F Bucar
Jun 21, 2003·Drug and Chemical Toxicology·Osama A BadaryMohamed H Abdel-Wahab
Aug 2, 2005·Research in Veterinary Science·K M FararhT Takewaki
Nov 9, 2005·International Immunopharmacology·Mohamed Labib Salem
Nov 30, 2005·The International Journal of Biochemistry & Cell Biology·Hala Gali-MuhtasibRegine Schneider-Stock
Feb 1, 2007·Annals of Saudi Medicine·Z A HawsawiA O Bamosa
Nov 18, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M KhaderP M Eckl
Apr 11, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Syed M QadriFlorian Lang
Nov 12, 2009·Life Sciences·Leelavinothan Pari, Chandrasekaran Sankaranarayanan
May 7, 2010·The Journal of Clinical Endocrinology and Metabolism·Michael Freemark
Aug 10, 2010·Critical Reviews in Food Science and Nutrition·Masood Sadiq Butt, Muhammad Tauseef Sultan
Oct 7, 2010·Nutrition and Cancer·Sanjeev BanerjeeRamzi M Mohammad
Jan 1, 2008·Radiology Case Reports·Joshua P SmithDesiree E Morgan

❮ Previous
Next ❯

Citations

Jun 5, 2021·Food & Function·Chandan SarkarMohammad S Mubarak

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
M H El-Dakdoky
Kokuritsu Iyakuhin Shokuhin Eisei Kenkyūjo hōkoku = Bulletin of National Institute of Health Sciences
K SakemiY Ohno
Archives of Environmental Contamination and Toxicology
J C KimM K Chung
© 2022 Meta ULC. All rights reserved