Acute effects of very-low-protein diet on FGF23 levels: a randomized study

Clinical Journal of the American Society of Nephrology : CJASN
Biagio Di IorioDomenico Russo

Abstract

High levels of fibroblast growth factor 23 are associated with mortality, CKD progression, and calcification in CKD patients. The aim of this pilot study is to assess whether a very-low-protein diet (0.3 g/kg per day) with a consequent low intake of phosphorus would reduce fibroblast growth factor 23 compared with a low-protein diet (0.6 g/kg per day) in CKD patients not yet on dialysis. A prospective, randomized, controlled crossover study was performed in which 32 patients were randomized into two groups. Group A (16 patients) received a very-low-protein diet (0.3 g/kg body wt per day) supplemented with ketoanalogues during the first week and a low-protein diet during the second week, and group B (16 patients) received a low-protein diet during the first week and a very-low-protein diet during the second week. Fibroblast growth factor 23, seric, and urinary phosphate levels were measured at baseline and the end of each study period. After only 1 week of the very-low-protein diet, reductions in fibroblast growth factor 23 levels (33.5%), serum phosphate (12%), and urinary phosphate (34%) with the very-low-protein diet compared with the low-protein diet were observed. Serum and urinary phosphate levels and protein intake were s...Continue Reading

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References

Aug 16, 1975·Lancet·R J Walton, O L Bijvoet
Nov 5, 2002·The Journal of Clinical Endocrinology and Metabolism·Yuji YamazakiSeiji Fukumoto
Jul 21, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Takashi ShigematsuMasafumi Fukagawa
Jul 31, 2004·Journal of the American Society of Nephrology : JASN·Geoffrey A BlockGlenn M Chertow
Dec 23, 2004·The Journal of Clinical Endocrinology and Metabolism·Serge L FerrariRené Rizzoli
May 27, 2005·Journal of the American Society of Nephrology : JASN·Orlando GutierrezMyles Wolf
Nov 9, 2005·American Journal of Physiology. Renal Physiology·Theresa J BerndtRajiv Kumar
Dec 13, 2005·Kidney International. Supplement·Eberhard RitzRalf Dikow
Mar 23, 2006·The Journal of Clinical Endocrinology and Metabolism·Erik A ImelMichael J Econs
Mar 28, 2006·Journal of the American Society of Nephrology : JASN·Claus Peter SchmittEberhard Ritz
Jun 1, 2006·The Journal of Clinical Endocrinology and Metabolism·Diana M AntoniucciAnthony A Portale
Jul 28, 2007·Journal of the American Society of Nephrology : JASN·Danilo FliserPeter Riegler
Apr 18, 2008·Journal of the American Society of Nephrology : JASN·Suresh MathewKeith A Hruska
Jun 24, 2008·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Vincenzo SavicaGuido Bellinghieri
Aug 9, 2008·The New England Journal of Medicine·Orlando M GutiérrezMyles Wolf
Oct 15, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Guillaume JeanCharles Chazot
Feb 5, 2009·Kidney International·Dominique PriéGérard Friedlander
Feb 13, 2009·JAMA : the Journal of the American Medical Association·Catherine SullivanAshwini R Sehgal
Apr 28, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Guillaume JeanCharles Chazot
Jul 1, 2009·Annals of Clinical Biochemistry·Annemieke C HeijboerMarinus A Blankenstein
Dec 8, 2009·Clinical Journal of the American Society of Nephrology : CJASN·Rodrigo B OliveiraRosa M A Moysés
Dec 17, 2009·Kidney International·Hirotaka Komaba, Masafumi Fukagawa
Dec 29, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Joachim H IxMary A Whooley
Jan 23, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Kamyar Kalantar-ZadehJoel D Kopple
Feb 4, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Tobias E Larsson
May 29, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Orlando M Gutiérrez
Jun 8, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Sarah SeilerGunnar H Heine
Jun 26, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Mehmet KanbayAdrian Covic
Jul 9, 2010·Kidney International·Mahmut I YilmazCarmine Zoccali
Jul 16, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Tamara IsakovaMyles Wolf
Nov 9, 2010·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Omar BeniniAdamasco Cupisti
Dec 25, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Sharon M MoeJohn R Asplin
Feb 25, 2011·Kidney International. Supplement·Keith HruskaToshifumi Sugatani
Feb 25, 2011·Kidney International. Supplement·Harald Jüppner
Jun 16, 2011·JAMA : the Journal of the American Medical Association·Tamara IsakovaUNKNOWN Chronic Renal Insufficiency Cohort (CRIC) Study Group
Jul 21, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Takashi ShigematsuUNKNOWN COLC Research Group
Sep 10, 2011·Journal of the American Society of Nephrology : JASN·Jessica KendrickUNKNOWN HOST Investigators
Oct 29, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Orlando M GutiérrezEric N Taylor
Dec 6, 2011·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Mahmut Ilker YilmazCarmine Zoccali

❮ Previous
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Citations

May 15, 2013·Current Opinion in Nephrology and Hypertension·Hannes Olauson, Tobias E Larsson
Mar 2, 2012·American Journal of Nephrology·Biagio Di Iorio, Antonio Bellasi
Feb 9, 2013·The Journal of Clinical Endocrinology and Metabolism·Robin A KremsdorfBryan R Kestenbaum
Feb 21, 2014·Current Opinion in Pediatrics·Markus J Kemper, Michael van Husen
Jun 12, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Giorgina B PiccoliFrancesco Porpiglia
Apr 2, 2014·Nature Reviews. Nephrology·Julia J Scialla, Myles Wolf
Mar 9, 2013·Clinical Journal of the American Society of Nephrology : CJASN·Tamara IsakovaMyles Wolf
Nov 13, 2013·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Aaltje Y AdemaUNKNOWN NIGRAM Consortium
Nov 8, 2012·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Biagio R Di IorioLucia Di Micco
Feb 16, 2015·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Anuja P ShahJoel D Kopple
Oct 5, 2012·Expert Opinion on Pharmacotherapy·Mario CozzolinoAndrea Galassi
Jul 13, 2016·BMC Nephrology·Vincenzo BellizziUNKNOWN “Conservative Treatment of CKD” study group of the Italian Society of Nephrology
Oct 18, 2016·The Medical Clinics of North America·Cheryl A M AndersonDena E Rifkin
May 16, 2017·Nutrients·Jacek RyszAnna Gluba-Brzózka
Sep 17, 2015·The Cochrane Database of Systematic Reviews·Zhuangzhu LiuWeizhong Ma
Oct 5, 2018·The Cochrane Database of Systematic Reviews·Deirdre HahnDenis Fouque
Oct 25, 2017·Nephrology·Grahame J ElderKelly Lambert
Jul 10, 2018·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Philippe ChauveauMichel Aparicio
May 15, 2015·Journal of the American Society of Nephrology : JASN·Tamara IsakovaGeoffrey A Block
Mar 1, 2014·Clinical Journal of the American Society of Nephrology : CJASN·Edward R Smith
May 11, 2019·International Journal of Molecular Sciences·Simona AdessoStefania Marzocco
Feb 9, 2018·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Wan-Chuan TsaiKuo-Liong Chien
Mar 5, 2020·Journal of Nephrology·Annet Bouma-de Krijger, Marc G Vervloet
Apr 3, 2020·Current Osteoporosis Reports·Elizabeth R StremkeKathleen M Hill Gallant
Nov 2, 2016·Current Opinion in Clinical Nutrition and Metabolic Care·Gang Jee KoKamyar Kalantar-Zadeh
Nov 26, 2013·Annals of Clinical Biochemistry·Edward R SmithStephen G Holt
Dec 13, 2016·Toxins·Piotr KuczeraAndrzej Wiecek
Jul 5, 2017·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Kazuki ShimoishiMasaki Otagiri
Oct 20, 2018·Journal of Clinical Medicine·Simona AdessoStefania Marzocco
Nov 9, 2019·Toxins·Isabel VogtMaren Leifheit-Nestler
Mar 28, 2020·Journal of the American Heart Association·Jonathan P LawCharles J Ferro
Nov 30, 2016·Clinical and Experimental Nephrology·Yutaka TaketaniKeitaro Yokoyama
May 30, 2019·Journal of Clinical Medicine·Lucia Di MiccoBiagio R Di Iorio
Jul 19, 2017·Annual Review of Nutrition·Lindsay R Pool, Myles Wolf
Oct 11, 2017·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Biagio R Di IorioLoreto Gesualdo

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