PMID: 25748407Mar 10, 2015Paper

Acute encephalopathy induced by vaccination in an infant with methylmalonic aciduria cblA

Zhonghua er ke za zhi. Chinese journal of pediatrics
Yu-Peng LiuYan-Ling Yang

Abstract

We report the first case of acute encephalopathy induced by vaccination in an infant with methylmalonic aciduria cblA in China. The clinical presentation, blood acylcarnitines analysis, urine organic acids analysis and gene studies of the patient were summarized. The proband, a boy, was admitted at the age of 15 months because of recurrent vomiting, acidosis and development delay for 8 months. The previously healthy boy presented vomiting and coma just one hour after hepatitis B vaccination at the age of seven months. Moderate dehydration, electrolyte disturbance and metabolic acidosis had been found. Although his acute metabolic crisis had been corrected soon after intravenous transfusion, psychomotor retardation and recurrent vomiting had been observed. When he was 15 months old, vomiting and lethargy occurred again 3 hours after DTaP vaccination. He was weakened as the illness became worse and got coma with dyspnea 7 days later. He was hospitalized with the suspected diagnosis of viral encephalitis. Blood acylcarnitines analysis, urine organic acids analysis and gene study had been performed for the etiologic investigation.His blood propionylcarnitine (16.3 µmol/L vs. normal range 1.0-5.0 µmol/L) and propionylcarnitine/free ...Continue Reading

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.

Related Papers

Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics
Yupeng LiuYan-Ling Yang
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics
Su-Qing QuHui Yang
Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences
Tao-yun JiYan-Ling Yang
© 2022 Meta ULC. All rights reserved