Acute ethanol and selected growth suppressor transcripts in regenerating rat liver

Alcohol
C K LumpkinJ K McClung

Abstract

To study the effects of acute ethanol on regenerating rat liver, the mRNA transcript levels of growth suppressor genes (prohibitin, TGF beta-1 and p53) were measured by Northern blot analysis during the G0, G1, and early S phases of compensatory growth after 70% partial hepatectomy (PH) in adult male rats. Selected animals were gavaged with either ethanol (3 g/kg) or glucose and underwent PH 1 h later. Other animals were either sham operated or underwent PH without gavage. Prohibitin and p53 transcripts were increased in relative abundance (as measured by an increase in band intensity) near the G1/S boundary (8-12 h post-PH) following both glucose and ethanol gavage. A transient increase in prohibitin transcripts at 0.5-1 h post-PH was found to be characteristic of glucose and nongavaged rats. Ethanol gavage significantly increased the relative abundance of prohibitin transcripts at 0.5-2 h post-PH. An increase in the TGF beta-1 transcripts at 4 h post-PH was found in the glucose and nongavaged rats. Ethanol gavage resulted in variable TGF beta-1 transcript expression near hepatectomy (0 h); however, mean differences were not statistically significant. Sham operation had no effect on the mRNA transcripts of the selected genes d...Continue Reading

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Citations

Mar 1, 1995·Experimental Gerontology·J K McClungR T Dell'Orco
Sep 26, 1997·Alcohol·I V Deaciuc
Jan 30, 2009·Pharmacogenetics and Genomics·Mercè CorreaGiovanni U Corsini
Oct 27, 2015·Cell and Tissue Research·Indrajit ChowdhuryWinston E Thompson
Aug 27, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jong Eun YeonSuzanne M De La Monte
Jun 27, 2006·Journal of Cellular and Molecular Medicine·Suresh MishraLiam J Murphy
May 24, 2017·Molecular Medicine Reports·Menggang Liu, Ping Chen
Dec 11, 1997·Infection and Immunity·S NarasimhanE K Spicer

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