PMID: 6113599Jan 1, 1980Paper

Acute ethanol effects on rat liver tryptophan oxygenase and tyrosine aminotransferase

Pharmacology, Biochemistry, and Behavior
H RouachR Nordmann

Abstract

In starved rats, ethanol administered acutely enhances tryptophan oxygenase (TO) and tyrosine aminotransferase (TAT) activities. Ethanol also inhibits the early phase of the cortisol-mediated TO and TAT induction. Ethanol administered at the same time as tryptophan does not modify the tryptophan-mediated TO and TAT induction. In cortisol-pretreated rats, ethanol enhances the subsequent TO and TAT induction whereas no additive effects are observed when ethanol is injected together with tryptophan. These results suggest that ethanol mimics the effects of tryptophan on TO and TAT activities. In fed animals, ethanol alone does not result in increased TO and TAT activities, but inhibits their cortisol induction. It increases TO activities when given together with a tryptophan dose which, when given alone, does not enhance these activities. It is suggested that the observed inhibitory effects of ethanol on cortisol-mediated TO and TAT induction in starved and fed animals are related to a defective cortisol transport in the liver cells.

References

Nov 8, 1972·Life Sciences. Pt. 2: Biochemistry, General and Molecular Biology·V M Sardesai, H S Provido
Jan 7, 1969·Biochimica Et Biophysica Acta·P O Seglen, K F Jervell
Jan 1, 1964·Advances in Enzyme Regulation·O Greengard
Feb 29, 1980·Biochimica Et Biophysica Acta·A R Pösö, H Pösö
Oct 1, 1964·Proceedings of the National Academy of Sciences of the United States of America·L D GARRENR M CROCCO

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Citations

Aug 1, 1972·Biochemical Pharmacology·Y GiudicelliR Nordmann
Sep 15, 1994·Biological Psychiatry·D LeMarquandC Benkelfat
Jun 1, 2002·Nutrition Research Reviews·Abdulla A-B Badawy
Mar 1, 1987·Revista Do Instituto De Medicina Tropical De São Paulo·D R VeigaO A Pereira

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