Acute Exercise Effects Predict Training Change in Cognition and Connectivity

Medicine and Science in Sports and Exercise
Michelle W VossGary L Pierce

Abstract

Previous studies report memory and functional connectivity of memory systems improve acutely after a single aerobic exercise session or with training, suggesting that the acute effects of aerobic exercise may reflect initial changes that adapt over time. In this trial, for the first time, we test the proof-of-concept of whether the acute and training effects of aerobic exercise on working memory and brain network connectivity are related in the same participants. Cognitively normal older participants (N = 34) were enrolled in a randomized clinical trial (NCT02453178). Participants completed fMRI resting state and a face working memory N-back task acutely after light- and moderate-intensity exercises and after a 12-wk aerobic training intervention. Functional connectivity did not change more after moderate-intensity training compared with light-intensity training. However, both training groups showed similar changes in cardiorespiratory fitness (CRF) (maximal exercise oxygen uptake, V˙O2peak), limiting group-level comparisons. Acute effects of moderate-intensity aerobic exercise on connections primarily in the default network predicted training enhancements in the same connections. Working memory also improved acutely, especiall...Continue Reading

Associated Clinical Trials

References

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Citations

Jan 1, 2021·Neuroscience and Biobehavioral Reviews·Tibor HortobágyiDavid Colomer-Poveda
Dec 2, 2020·Annual Review of Medicine·Patrick J Smith, Rhonda M Merwin
Jan 14, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Emily ErlenbachNeha P Gothe
Feb 9, 2021·Frontiers in Physiology·Samuel R WeaverSamuel J E Lucas
Nov 6, 2020·Experimental Gerontology·Stephanie M Muscat, Ruth M Barrientos
Jun 9, 2021·Hippocampus·Sarah L AghjayanKirk I Erickson
Jul 22, 2021·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Dongsuk SungCandace C Fleischer

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