PMID: 7089466Mar 25, 1982Paper

Acute experimental bone marrow necrosis in the rabbit induced by aortic ligation. Ultrastructural and biochemical study

Revue du rhumatisme et des maladies ostéo-articulaires
B MazièresJ Arlet


The authors study the effects of ligation of the infra-renal aorta on the bone marrow in the femoral shafts in ten rabbits, from a histopathological and biochemical standpoint. Histology revealed marrow necrosis in nine cases out of ten. They describe the appearances of this necrosis by light and electron microscopy. In five cases it was focal and partial and in four cases total. It sometimes involved only the haematopoietic tissue, leaving fatty tissue unaffected. The latter would thus seem to be more resistant to ischaemia. Study of lipids showed a decrease in polyunsaturated fatty acids, a decrease which was more marked in the ischaemic femurs than in the humerus of the same rabbits.

Related Concepts

Fat Pad
Abdominal Aorta Structure
Hematopoiesis, Medullary
Electron Microscopy
Lipid Metabolism

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