PMID: 2499980Jan 1, 1989Paper

Acute experimental glomerulonephritis induced by the glomerular deposition of circulating polymeric IgA-concanavalin A complexes

Virchows Archiv. A, Pathological Anatomy and Histopathology
J C DavinP Mahieu

Abstract

The perfusion of polymeric or secretory IgA-Concanavalin A complexes into the aorta of rats led to a mannose-dependent binding of both IgA and lectin to the glomerular capillary wall, as shown by double immunolocalization experiments, by quantitative analysis of the amount of radiolabelled complexes bound per g of kidney, and by blocking experiments with the corresponding carbohydrate. Rats injected with amounts of those complexes as low as 500 micrograms developed, one hour later, a focal and segmental proliferative glomerulonephritis characterized by the deposition of injected complexes and of rat C3 and rat fibrin/fibrinogen in most glomeruli; focal thrombosis and small areas of necrosis in 10 to 15% of glomeruli, confined to the periphery of a single lobule of the tuft and segmental infiltration of these glomeruli by polymorphonuclear leucocytes and platelets. At the same time, many mesangial cells exhibited a hyperactive appearance, and red blood cells were noted in tubular lumens. In contrast, rats similarly injected with either monomeric IgA-ConA complexes, multimeric or secretory IgA-peanut agglutinin complexes or polymeric or monomeric IgA aggregates of comparable apparent molecular weight did not develop obvious glome...Continue Reading

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Citations

Sep 1, 1990·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·J F Knight
Jan 1, 1994·Pathology International·Y Endo, H Kanbayashi
Apr 1, 1991·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·R CoppoY Tomino
Jun 30, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Y OguraN Yoshikawa
Apr 30, 2009·Pediatrics International : Official Journal of the Japan Pediatric Society·Andrew FretzayasPolyxeni Nicolaidou
Nov 23, 2019·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Hernán Trimarchi, Rosanna Coppo
Jan 5, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Takashi SanoYutaka Kobayashi
Dec 21, 2019·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Rosanna Coppo, Christophe Mariat

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