Acute exposure of rabbits to diphenyl diselenide: a toxicological evaluation

Journal of Applied Toxicology : JAT
Marcos Raniel StraliottoAndreza Fabro de Bem

Abstract

The simple organoselenium compound diphenyl diselenide (PhSe)(2) is a promising new pharmacological agent. However, few toxicological evaluations of this molecule have been reported. We evaluated the effects of acute administration of (PhSe)(2) on toxicological parameters in rabbits. Adult New Zealand rabbits were exposed to (PhSe)(2) (5-500 micromol kg(-1) , intraperitoneally) once a day for 5 days. Exposure to 500 micromol kg(-1) caused 85% mortality. Exposure to 50 micromol kg(-1) of (PhSe)(2) increased the glutathione levels in the hippocampus, kidney, heart, muscle and blood, whereas lipoperoxidation (TBARS) decreased in the cerebellum and kidney after exposure to 5 micromol kg(-1) . The activity of glutathione peroxidase increased in the heart and muscle of rabbits treated with 50 micromol kg(-1) of (PhSe)(2) and glutathione reductase activity was reduced in the cerebellum, cerebral cortex and kidney. Treatment with (PhSe)(2) reduced the activity of δ-aminolevulinate dehydratase in the hippocampus and increased this activity in the heart, but did not alter the activity of complexes I and II of the respiratory chain in the liver and brain. Hepatic and renal biochemical and histological parameters were not modified by (PhSe...Continue Reading

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Citations

Jul 2, 2011·Archives of Toxicology·Cristina W Nogueira, João B T Rocha
Aug 3, 2012·Journal of Toxicology and Environmental Health. Part a·R A SaraivaJ B T Rocha
Oct 29, 2011·Neurochemistry International·Natalí L ChanadayGerman A Roth
Feb 4, 2012·Toxicologic Pathology·Edovando J F da RosaFélix Alexandre Antunes Soares
May 12, 2011·Journal of Cardiovascular Pharmacology·Mariana Appel HortRosa Maria Ribeiro-do-Valle
Sep 4, 2019·Drug and Chemical Toxicology·Mariana Appel HortFlavio Manoel Rodrigues da Silva Júnior
Apr 2, 2021·Archives of Toxicology·Cristina W NogueiraJoão B T Rocha

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