Acute exposure of uranyl nitrate causes lipid peroxidation and histopathological damage in brain and bone of Wistar rat

Journal of Environmental Pathology, Toxicology and Oncology : Official Organ of the International Society for Environmental Toxicology and Cancer
Somnath GhoshKaushala Prasad Mishra

Abstract

Although the kidneys are the main target organs for uranium (U) toxicity, recent studies have shown that U can cross the blood-brain barrier to accumulate in the brain. Uranyl nitrate (U-238)induced oxidative damage was investigated in brain and bone of Wistar rats after intraperitoneal injection of uranyl nitrate at acute doses either nephrotoxic (576 microg of U/kg body weight) or subnephrotoxic (144 microg U/kg body weight). The health effects of U administration at 576 microg of U/kg body weight were seen in terms of decrease in food intake and no gain in body weight compared to respective controls. These alterations were correlated with increased lipid peroxidation as measured by thiobarbituric acid reactive substances in rat brain and bone. However, at lower dosage of U (144 microg U/kg body weight), no significant lipid peroxidation was observed in brain and bone. Histological examination of U-treated (576 microg of U/kg body weight) rat brain tissues showed marked and diffuse cystic degeneration and a similar pattern in histological alterations was observed in kidneys in treated animals; whereas no significant histological change was observed in rat brains and kidney treated with a lower dose of U (144 microg U/kg body ...Continue Reading

Citations

Mar 3, 2010·International Journal of Environmental Research and Public Health·Wayne Briner
Oct 8, 2013·Radiation and Environmental Biophysics·Branislava MitrovićDuško Vitorović
Jun 18, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Luis GuzmánLeonardo S Santos
Apr 29, 2009·International Journal of Radiation Biology·Amit KumarKaushala Prasad Mishra
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Apr 12, 2019·Radiation and Environmental Biophysics·Branislava MitrovićBorjana Vranješ
Aug 7, 2020·Journal of Environmental Radioactivity·Yonghong RanYuhui Hao
Aug 15, 2009·Chemical Research in Toxicology·Maria G Benavides-Garcia, Krishnan Balasubramanian

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