PMID: 8964649Dec 1, 1995Paper

Acute exposure to morphine suppresses cytotoxic T-lymphocyte activity

International Journal of Immunopharmacology
G W CarpenterD J Carr

Abstract

Chronic exposure (11 days) to morphine has previously been shown to suppress splenic and peritoneal cytotoxic T-lymphocyte activity through mu-opioid receptors. The present study was undertaken to assess the effects of varying the frequency of exposure to morphine on cytotoxic T-lymphocyte activity in C3H/HeN mice immunized with C57BL/6 splenocytes. Mice subchronically treated with morphine (50.0 mg/kg) showed no measurable suppression of splenic natural killer activity or splenic or peritoneal cytotoxic T-lymphocyte activity. However, mice treated acutely with 50.0 mg/kg of morphine exhibited a significant suppression of peritoneal but not splenic cytotoxic T-lymphocyte activity. Naltrexone pretreatment of mice receiving an acute dose of morphine blocked the suppression, implicating the involvement of opioid receptors. Using column depletion chromatography, peritoneal exudate cells mediating cytotoxic T-lymphocyte activity were both CD4+CD8- and CD4-CD8+. Collectively, the results suggest that the duration of opioid (morphine) exposure differentially affects peritoneal cytotoxic T-lymphocyte activity. These results may have important implications regarding immunity to viral infections in individuals who abuse drugs such as her...Continue Reading

Citations

Jun 1, 1997·British Journal of Pharmacology·P SacerdoteA E Panerai
Jul 25, 2006·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Keith Budd
Dec 6, 2000·Immunopharmacology and Immunotoxicology·R L SciorsciP Minoia
Jun 19, 2019·Expert Opinion on Drug Metabolism & Toxicology·Farzin Khosrow-KhavarAntonios Douros
Aug 1, 1997·Natural Product Reports·K W Bentley

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