PMID: 3584732Apr 1, 1987Paper

Acute extracellular magnesium deficiency and myocardial tolerance to ischemia

Journal of the American College of Nutrition
P C BorchgrevinkP Jynge

Abstract

The present study was undertaken in order to assess the effects of an acute and purely extracellular depletion of Mg during subtotal global ischemia and/or during post-ischemic reperfusion in the isolated rat heart. Mg depletion during reperfusion only or during ischemia plus reperfusion induced a significant reduction in post-ischemic recovery of cardiac function. Mg depletion during ischemia alone induced only a minor reduction in inotropy and coronary flow. Myocardial ATP at the end of the experiment was lowered in the groups of hearts deprived of Mg during ischemia plus reperfusion or during reperfusion only. A secondary finding was the demonstration of positive chronotropic and negative inotropic effects of the removal of extracellular Mg in non-ischemic hearts. It is concluded that, in a minor to moderate ischemic injury as in the present study, acute removal of extracellular Mg may lead to impairment of post-ischemic cardiac function and metabolism.

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Citations

Aug 1, 1997·The Annals of Thoracic Surgery·W Storm, J J Zimmerman
Nov 30, 2004·Critical Care : the Official Journal of the Critical Care Forum·Kees H Polderman, Armand R J Girbes
Jan 1, 1993·Progress in Cardiovascular Diseases·M A Arsenian
Apr 1, 1988·Disease-a-month : DM·R J Elin
Jul 17, 1998·Anesthesiology·M N Gomez
Oct 16, 1999·Hypertension·M BarbagalloL M Resnick
Sep 1, 1996·Clinical and Experimental Pharmacology & Physiology·Y SongM Vassalle
Feb 1, 1989·The American Journal of Physiology·Z S AgusM Morad

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