Acute extracellular matrix, inflammatory and MAPK response to lengthening contractions in elderly human skeletal muscle

Experimental Gerontology
Jacob R SorensenRobert D Hyldahl

Abstract

To uncover potential factors that may be involved in the impaired regenerative capacity of aged skeletal muscle, we comprehensively assessed the molecular stress response following muscle damage in old and young individuals. 10 young (22.7 ± 2.25 yrs) and 8 physically active old (70.9 ± 7.5 yrs) subjects completed a bout of 300 lengthening contractions (LC), and muscle biopsies were taken pre-exercise and at 3, 24, and 72 h post-LC. Both age groups performed the same amount of work during LC, with the old group displaying a resistance to LC-induced fatigue during the exercise. Muscle damage was evident by soreness and losses in isokinetic force and power production, though older subjects experienced reduced force and power losses relative to the young group. The acute extracellular matrix (ECM) response was characterized by substantial increases in the glycoproteins tenascin C and fibronectin in the young, which were blunted in the old muscle following damage. Old muscle displayed a generally heightened and asynchronous inflammatory response compared to young muscle, with higher expression of MCP-1 that appeared at later time points, and increased NF-κb activity. Expression of the stress-related MAPKs P38 and JNK increased only...Continue Reading

Citations

Jun 19, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jacob R SorensenRobert D Hyldahl
Sep 17, 2019·Exercise and Sport Sciences Reviews·Paul T ReidyMicah J Drummond
Jul 31, 2019·Journal of Strength and Conditioning Research·Dustin J OranchukJohn B Cronin
Oct 9, 2019·American Journal of Physiology. Endocrinology and Metabolism·Denisse Valladares-IdeHermann Zbinden-Foncea
Oct 1, 2020·International Journal of Molecular Sciences·Matthias GumpenbergerRobert Csapo
Oct 9, 2018·European Journal of Sport Science·Barbara WessnerRobert Csapo
Mar 15, 2020·European Journal of Applied Physiology·Georgios MavropaliasKazunori Nosaka
May 6, 2021·Journal of Cachexia, Sarcopenia and Muscle·Colleen S DeaneTimothy Etheridge
Sep 7, 2021·The Journal of Physiology·Robert D HyldahlJayson R Gifford

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