PMID: 2508387Sep 1, 1989Paper

Acute facilitory action of progesterone on gonadotropin secretion of perifused rat pituitary cells

Acta Endocrinologica
O OrtmannG Emons

Abstract

The purpose of this study was to investigate the kinetics and estrogen dependence of the facilitory progesterone action on LH and FSH secretion from pituitary cells under dynamic culture conditions. Anterior pituitary cells obtained from ovariectomized or intact adult Wistar rats were cultivated on Cytodex 1 microcarrier beads. The perifusion experiments were performed with four separate perfusion chambers. The cells of chambers I + II had been pretreated with medium containing vehicle (0.1% ethanol), those of chambers III + IV with medium containing 1 nmol/l estradiol for 48 h. After perfusion was started, each of the chambers was challenged with an initial 2-min GnRH (1 nmol/l) pulse. Chamber I was further perifused with medium containing vehicle, chamber II with medium containing vehicle + 100 nmol/l progesterone, chamber III with medium containing 1 nmol/l estradiol, and chamber IV with medium containing 1 nmol/l estradiol + 100 nmol/l progesterone. Three further GnRH pulses were administered at 50-min intervals to each of the chambers. In estradiol-primed cells from intact rats, progesterone induced a positive effect on LH and FSH secretion after 50 min of exposure to progesterone. After 100 min of progesterone treatment, ...Continue Reading

Citations

Jan 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·G Schaison, B Couzinet
Jun 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·L A Lesoon, V B Mahesh
Dec 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·O OrtmannG Emons
Jan 1, 1994·The Journal of Steroid Biochemistry and Molecular Biology·O OrtmannK J Catt
Dec 1, 1992·Trends in Endocrinology and Metabolism : TEM·J L Turgeon, D W Waring
Feb 7, 2001·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·J DonathH Michna

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