PMID: 3214385Feb 1, 1988Paper

Acute fatty liver of pregnancy: clinical features and diagnosis

The Australian & New Zealand Journal of Obstetrics & Gynaecology
J M Purdie, B N Walters

Abstract

Five cases of acute fatty liver of pregnancy are described. These are the only recognized cases of this disorder occurring in a 2 year period in Western Australia. Clinical and laboratory features are presented. There was no maternal death. Of the six babies, there were three intrauterine deaths, including the only set of twins. All the babies were male. Vomiting in the third trimester was the chief presenting feature in all cases, often accompanied by a systemic illness with malaise and tiredness. Extreme polydipsia was noted as a prominent symptom in all cases. The combination of moderately abnormal liver function tests, extreme leucocytosis with other blood film abnormalities, hypoglycaemia, impaired renal function, coagulopathy and gross elevation of uric acid level is regarded as highly suggestive of the diagnosis. Features of a preeclamptic illness were present in several cases. Three of the patients have since had uneventful pregnancies. The constellation of clinical and laboratory features is sufficiently characteristic to allow accurate clinical diagnosis in most cases of this disorder. The chances of both maternal and fetal survival are enhanced by early diagnosis allowing intervention in the form of prompt delivery o...Continue Reading

References

Feb 1, 1986·British Medical Journal·C M McKeeM E Callender
Sep 1, 1986·Annals of Internal Medicine·B CampilloJ P Benhamou
Aug 8, 1985·The New England Journal of Medicine·M M Kaplan
Jan 5, 1985·British Medical Journal·M de Swiet
Apr 1, 1970·The Journal of Obstetrics and Gynaecology of the British Commonwealth·E E Wood
Jan 1, 1984·Medicine·P J PockrosT B Reynolds
Feb 16, 1984·The New England Journal of Medicine·W M BarronM D Lindheimer
Apr 1, 1983·Gut·J BernuauJ P Benhamou

❮ Previous
Next ❯

Citations

Apr 25, 2003·Medical Hypotheses·Charles G Coffey
Apr 1, 1992·Australian and New Zealand Journal of Medicine·E J GaneM R Lane
Oct 14, 2009·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·R PadmagirisonE H Kevelighan
Nov 1, 1994·American Journal of Obstetrics and Gynecology·I M UstaB M Sibai
Jan 28, 2005·Journal of Obstetric, Gynecologic, and Neonatal Nursing : JOGNN·Patricia A Jamerson
Mar 1, 1992·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·M MakkonenS Saarikoski
Oct 18, 2008·Journal of Hepatology·Harshad DevarbhaviLakshmi Padmanabhan
Jan 6, 2006·Obstetrics and Gynecology·Marsha F BrowningVivian E Shih
Apr 1, 1992·Genitourinary Medicine·R J Gilson
May 1, 1994·British Journal of Obstetrics and Gynaecology·S KennedyW M Hague
Sep 30, 2010·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Phyllis Glanc, Cynthia Maxwell

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

© 2021 Meta ULC. All rights reserved