PMID: 7370773Apr 28, 1980Paper

Acute FeCl3-induced epileptogenic foci in cats: electrophysiological analyses

Brain Research
S A Reid, G W Sypert

Abstract

Fifteen cats were rendered acutely epileptic via transpial iontophoresis of ferric ions. Extracellular electrical activity of individual cortical neurons was temporally correlated with ECoG epileptic spikes. Each unit's activity was characterized as excited, inhibited, or unaffected. The spatial coordinates of each neuron were logged, thereby generating a 3-dimensional activity map. Discharge patterns were further classified as bursting or non-bursting. A significantly increased population of inhibited cells was detected at radial distances greater than 3 mm from the iontophoretic site. This increase was at the expense of "unaffected-bursting" cells. Pathological discharge patterns, including units which fired in long-first-interval bursts, were common in the focus. A system was designed to electronically calculate single-unit firing probability before, during and after surface epileptiform spikes. An 8-12 Hz oscillation in firing probability level, time-locked to the epileptic spike, was observed in most excited-bursting units. Many of these findings in the ferric-induced epileptic focus accurately model the electrophysiological characteristics previously reported for human epileptic foci examined at neurosurgery.

References

Dec 1, 1975·Electroencephalography and Clinical Neurophysiology·B IshijimaK Hirakawa
Mar 1, 1976·Electroencephalography and Clinical Neurophysiology·T L Babb, P H Crandall
Mar 1, 1979·Electroencephalography and Clinical Neurophysiology·P GloorG K Kostopoulos
Sep 1, 1976·Experimental Neurology·E M SchmidtJ S McIntosh
May 1, 1977·Experimental Neurology·P A SchwartzkroinB Bromly
Oct 1, 1970·Electroencephalography and Clinical Neurophysiology·I Sherwin
Aug 1, 1967·Electroencephalography and Clinical Neurophysiology·J D Frost, M D Low
Sep 1, 1973·Experimental Neurology·A R WylerA A Ward
Dec 1, 1973·Experimental Neurology·A R WylerA A Ward
Feb 1, 1967·Archives of Neurology·D A Prince, B J Wilder
Apr 1, 1965·Electroencephalography and Clinical Neurophysiology·R E DUSTMAN, E C BECK

❮ Previous
Next ❯

Citations

Jul 1, 1985·Biological Psychiatry·J G CsernanskyL E Hollister
Jan 1, 1988·Electroencephalography and Clinical Neurophysiology·S Veregge, J D Frost
Jan 24, 1983·Life Sciences·J G CsernanskyL E Hollister
Jun 1, 2002·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Nihei YamamotoIsao Yokoi
Jan 14, 1982·Brain Research·R M Dasheiff, J O McNamara
Apr 1, 1984·Journal of Neurochemistry·W J Triggs, L J Willmore
Sep 24, 1986·Brain Research·L J WillmoreJ D Gray
Apr 1, 2008·Human & Experimental Toxicology·R HazraD Guha
Aug 9, 2006·Expert Review of Neurotherapeutics·Carlo Alberto Pagni, Francesco Zenga
May 1, 1994·Journal of Neurochemistry·S C GilmanT C Pellmar

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.