Acute fibrinous and organizing pneumonia: A case report

Medicine
Yuanhui WangChuanlong Zhu

Abstract

Acute fibrinous and organizing pneumonia (AFOP) is an uncommon type of acute lung injury associated with infection, connective tissue disorders, drug exposure, and hematologic malignancies. A 53-year-old female presented with intermittent fever, chills, and dry cough since 10 days. Chest computed tomography scan showed multiple bilateral patchy infiltrates. PPD skin test was positive but tuberculosis antibody test and T-SPOT were negative. Histologic examination revealed massive fibrinous exudation with organization within alveolar spaces and scattered neutrophilic infiltrates, which was consistent with AFOP. This patient was treated with prednisolone therapy. Chest radiograph improvement and symptom improvement, including fever and respiratory symptoms, was observed after 2 week of oral prednisolone treatment. After 9-month of treatment, the patient was asymptomatic with stable disease and improved quality of life. AFOP has unique pathologic manifestations; however, the condition is liable to be misdiagnosed as community-acquired pneumonia ortuberculosis. Antibiotics are ineffective, while some patients show good response to glucocorticoid therapy.

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Citations

Apr 25, 2020·Intensive Care Medicine·Marie-Christine CopinUNKNOWN Lille COVID-19 ICU and Anatomopathology Group
Mar 27, 2021·Medicina intensiva·H MerdjiUNKNOWN CRICS TRIGGERSEP Group (Clinical Research in Intensive Care, Sepsis Trial Group for Global Evaluation, Research in Sepsis)
Jun 2, 2021·Medicina Intensiva·H MerdjiUNKNOWN CRICS TRIGGERSEP Group (Clinical Research in Intensive Care, Sepsis Trial Group for Global Evaluation, Research in Sepsis)
Jun 1, 2021·Medicina intensiva·H MerdjiUNKNOWN CRICS TRIGGERSEP Group (Clinical Research in Intensive Care, Sepsis Trial Group for Global Evaluation, Research in Sepsis)
Oct 12, 2021·Diagnostic Pathology·Haihong ChenKe-Jing Tang

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Methods Mentioned

BETA
biopsy
hysterectomy

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Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine
Prashant SaxenaArti Vashisth
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