Abstract
A beneficial memory effect of acute fornix deep brain stimulation (DBS) has been reported in clinical studies. The aim of this study was to investigate the acute changes in glucose metabolism induced by fornix DBS. First, the Morris water maze test and novel object recognition memory test were used to confirm declined memory in aged mice (C57BL/6, 20-22 months old). Then, four groups of mice were used as follows: aged mice with stimulation (n = 12), aged mice with sham-stimulation (n = 8), adult mice (3-4 months old) with stimulation (n = 12), and adult mice with sham-stimulation (n = 8). Ipsilateral hippocampal glucose metabolism and glutamate levels were measured in vivo by microdialysis before, during, and after fornix DBS treatment. Histological staining was used to verify the localization of electrodes and mice with inaccurate placement were excluded from subsequent analyses. The effects of fornix DBS on extracellular glucose, lactate, pyruvate, and glutamate levels over time were analyzed by repeated-measures analysis of variance followed by Fisher's least significant difference post hoc test. The aged mice had a higher basal lactate/pyruvate ratio (LPR) and lactate/glucose ratio (LGR) than the adult mice (LPR: 0.34 ± 0.0...Continue Reading
References
Mar 1, 1987·Neurobiology of Aging·G B Freeman, G E Gibson
Jul 14, 1995·Mechanisms of Ageing and Development·P Saransaari, S S Oja
Sep 1, 1997·Journal of Neurochemistry·L Massieu, R Tapia
Jan 31, 2008·Annals of Neurology·Clement HamaniAndres M Lozano
May 28, 2009·Learning & Memory·Catherine C Kaczorowski, John F Disterhoft
Aug 6, 2010·Annals of Neurology·Adrian W LaxtonAndres M Lozano
Nov 3, 2010·Proceedings of the National Academy of Sciences of the United States of America·Jaime M RossLars Olson
Mar 14, 2012·Nature Reviews. Neurology·Majid FotuhiClifford Jack
Mar 15, 2015·ELife·Albert LiuLee Wei Lim
Mar 31, 2015·Brain Stimulation·Tejas SankarAndres M Lozano
Sep 1, 2015·Brain Stimulation·Elise GondardAndres M Lozano
Oct 16, 2015·Nature·Shuang HaoJianrong Tang
Nov 26, 2015·Brain Structure & Function·Sarah HeschamYasin Temel
Dec 20, 2015·Journal of Neurosurgery·Francisco A PonceUNKNOWN ADvance Research Group
Feb 11, 2016·Acta Neurologica Scandinavica·H S JeongS J Rhie
Mar 24, 2016·ELife·Xinde ZhengTony Hunter
Dec 7, 2016·Frontiers in Integrative Neuroscience·Wissam DeebMichael S Okun
Sep 14, 2017·Ageing Research Reviews·Syed Zahid Ali ShahLifeng Yang