Acute gastro-intestinal bleeding in the critically ill patient

Intensive Care Medicine
J R Croker

Abstract

Endoscopic studies have shown that all critically ill patients are liable to a degree of stress ulceration. Diffuse erosions appear first in the fundus and then spread to the corpus and antrum within 48 h. Duodenal disease is particularly common in burns patients. Discrete ulceration occurs in most severely injured patients. Mucosal damage is probably initiated by ischaemia but only develops in the presence of acid. Although related to the severity of underlying illness, haemorrhage is unpredictable. Mortality is high and largely unaffected by treatment. Emphasis should therefore be made on prophylaxis. Improved intensive reducing intra-luminal acid by antacid or H2 receptor antagonists appears to be the most effective measure, but controlled studies are required.

References

Oct 1, 1976·Annals of Surgery·S J Simonian, L E Curtis
Aug 1, 1976·The Journal of Trauma·J C McAlhanyB A Pruitt
Sep 1, 1975·American Journal of Surgery·R H JamaT Matsumoto
May 11, 1975·Archives of Surgery·A J CzajaB A Pruitt
Apr 1, 1973·American Journal of Surgery·J J Byrne, V A Guardione
Apr 1, 1973·The British Journal of Surgery·E A Lewis
Apr 1, 1973·Current Problems in Surgery·J F StrempleG B Glass
Aug 1, 1970·Archives of Surgery·L NortonB Eiseman
Oct 1, 1970·Annals of Surgery·B A PruittJ A Moncrief
Apr 1, 1971·Archives of Surgery·C E LucasA J Walt
Feb 1, 1969·Journal of Neurosurgery·C C Watts, K Clark

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Citations

May 24, 1980·Lancet·P StenbergI M Nilsson
May 24, 1980·Lancet·H Holden
May 24, 1980·Lancet·P Dawes, S T Atherton
Mar 1, 1982·Surgical Neurology·O B LeramoA R Hudson
Apr 1, 1987·Journal of the American College of Nutrition·K SriramG C Santiago
Jul 28, 2005·The British Journal of Radiology·R KumarA Malhotra
Aug 17, 2005·Scandinavian Journal of Caring Sciences·Febe Friberg, Marianne Hansson Scherman
Jul 18, 2006·Diabetic Medicine : a Journal of the British Diabetic Association·H Hearnshaw, A Lindenmeyer
Sep 14, 2001·Pediatric Annals·R Kulkarni
Aug 1, 1985·Anaesthesia and Intensive Care·K Hillman
Feb 1, 1988·Alimentary Pharmacology & Therapeutics·J MarchantJ R Wood

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