PMID: 3899668Jan 1, 1985Paper

Acute haemodynamic effects of felodipine in congestive heart failure

European Journal of Clinical Pharmacology
H EmanuelssonF Waagstein

Abstract

The haemodynamic effects of felodipine 0.1 mg/kg p.o., a new arteriolar dilator, were studied in 7 patients with severe congestive heart failure of NYHA Class IV (Group A) and in 3 patients in Class II-III (Group B). In Group A, measurements were made before and 1 and 4 h after felodipine administration. There was a substantial fall in systemic arterial pressure, which was not associated with a compensatory tachycardia. In fact, there was a fall in heart rate from 92 to 82 beats/min 1 h after drug administration. The pulmonary capillary wedge pressure was reduced from 22 to 14 mm Hg and the cardiac index and stroke volume index rose significantly. Consequently, there was a marked reduction in systemic vascular resistance. In Group B measurements were performed at rest and during exercise before and 1 h after felodipine. The pulmonary wedge capillary pressure during exercise was lower than in the control situation. Coronary sinus flow was increased and there was a pronounced fall in coronary vascular resistance. The results would suggest that felodipine, by virtue of its ventricular unloading potency, might be a valuable drug in the treatment of congestive heart failure.

References

Aug 1, 1979·The American Journal of Cardiology·D H FitchettJ F Goodwin
Jan 1, 1985·Drugs·M BeenW S Hillis
Apr 1, 1972·The Journal of Clinical Investigation·C B HigginsE Braunwald
May 1, 1982·Progress in Cardiovascular Diseases·R E Goldstein
Sep 1, 1983·The American Journal of Cardiology·J M DetryJ Renkin
Apr 1, 1984·British Heart Journal·A D TimmisD E Jewitt
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Feb 1, 1980·British Heart Journal·P D BourdillonG C Sutton
Jan 1, 1984·Journal of Pharmaceutical and Biomedical Analysis·M Ahnoff

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Citations

Aug 1, 1987·Cardiovascular Drugs and Therapy·G BinettiB Magnani
Jan 1, 1991·International Journal of Cardiology·P AgostoniA Polese
Nov 1, 1991·DICP : the Annals of Pharmacotherapy·K C Yedinak, L M Lopez
Jul 1, 1986·Acta Pharmacologica Et Toxicologica·J Askholt, F Nielsen-Kudsk

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