Acute haemodynamic effects of pinacidil in man

British Journal of Clinical Pharmacology
D P NichollsR G Shanks

Abstract

The acute haemodynamic effects of i.v. pinacidil 0.2 mg kg-1 infused over 8 min were studied in 10 normotensive patients undergoing cardiac catheterisation. Mean arterial pressure fell from 94 +/- 3 mmHg (mean +/- s.e. mean) before infusion to 74 +/- 3 mmHg at 10 min after commencing infusion (P less than 0.001) and during this time heart rate increased from 75 +/- 4 to 106 +/- 7 beats min-1 (P less than 0.001). Significant changes were recorded until the end of the observation period (70 min after commencing infusion). Cardiac index increased from 3.2 +/- 0.2 to 4.0 +/- 0.2 l min-1 m-2 (P less than 0.001) and systemic vascular resistance fell from 16 +/- 1 to 10 +/- 1 units (P less than 0.001) at 10 min after commencing infusion. By the end of the observation period, the values had returned to pre-infusion levels. Only small changes in pulmonary haemodynamics were observed. These results indicate that pinacidil acts as a peripheral arteriolar vasodilator, and as such may have a role in the treatment of arterial hypertension and of cardiac failure.

References

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Citations

Jan 1, 1989·European Journal of Clinical Pharmacology·J L SaumetJ P Boissel
Jun 27, 2001·Bioorganic & Medicinal Chemistry Letters·T M TagmoseJ B Hansen
Jan 1, 1991·British Journal of Clinical Pharmacology·C ThuillezJ F Giudicelli
Jan 1, 1988·Clinical and Experimental Hypertension. Part A, Theory and Practice·M P Cinquegrani, C S Liang
Aug 1, 1989·British Journal of Pharmacology·C Damase-MichelP Montastruc
Jan 1, 1989·Pharmacology & Toxicology·C B NielsenF Nielsen-Kudsk

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