PMID: 2494609Jan 2, 1989Paper

Acute haloperidol administration induces depolarization block of nigral dopamine neurons in rats after partial dopamine lesions

Neuroscience Letters
J R Hollerman, A A Grace

Abstract

The effects of the antipsychotic drug haloperidol (HAL) on the electrophysiological activity of dopamine (DA)-containing cells in the substantia nigra was assessed in rats 6 weeks after partial 6-hydroxydopamine (6-OHDA)-induced lesions of the nigrostriatal DA pathway. Depleting 75% or more of striatal DA altered the response of DA neurons to acute HAL administration. Whereas acute HAL administration generally accelerates DA neuron firing in control rats, similar HAL doses given to lesioned rats not only increased firing rate but induced depolarization block of DA neuron spike generation similar to that resulting from chronic neuroleptic administration. In contrast, acute administration of doses of HAL up to lethal levels typically could not induce depolarization block of DA neurons in non-lesioned rats. This preparation thus could be an effective model for investigating the exacerbation of behavioral deficits produced by an increased demand placed upon a compromised DA system, as may occur in Parkinson's disease or with antipsychotic drug treatment.

References

Jan 1, 1977·Schizophrenia Bulletin·G E Hogarty
Jan 1, 1979·Progress in Neuro-psychopharmacology·B BeckmannE Rüther
Nov 1, 1985·Annals of Neurology·A M SnyderM J Zigmond
Apr 1, 1973·The Journal of Pharmacy and Pharmacology·N E Andén, G Stock
Apr 1, 1973·The British Journal of Psychiatry : the Journal of Mental Science·G E Crane

❮ Previous
Next ❯

Citations

Jul 1, 1992·Biulleten' eksperimental'noĭ biologii i meditsiny·R R GaĭnetdinovK S Raevskiĭ
Jan 1, 1993·Journal of Neural Transmission. General Section·A A Grace
Jan 1, 1994·Journal of Neural Transmission. General Section·A WolkinJ Rotrosen
Jan 1, 1991·Journal of Neural Transmission. Parkinson's Disease and Dementia Section·N C Harris, S A Greenfield
Jan 1, 1992·Progress in Neuro-psychopharmacology & Biological Psychiatry·M R Lynch
Feb 24, 2006·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Shitij KapurMing Li
Nov 14, 2006·Biochemical Pharmacology·Eric A StoneMichael L Lehmann
Sep 11, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Anthony A Grace
Mar 14, 2007·International Review of Neurobiology·Yukiori Goto, Anthony A Grace

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here