Acute health-related quality of life in children undergoing stem cell transplant: I. Descriptive outcomes

Bone Marrow Transplantation
S PhippsS N Rai

Abstract

There has been little empirical documentation of the acute effects of bone marrow or stem cell transplant (BMT) on children. In the present study, the responses of 153 children undergoing BMT were assessed in a prospective, longitudinal design. Children were assessed at the time of admission for transplant, then underwent weekly assessments to week +6, followed by monthly assessment to month +6. Data were obtained both by parent report and patient report (for patients age 5 and up) using the BASES scales. The major findings are: (1) children undergoing BMT enter the hospital with an already heightened level of distress (defined by high levels of somatic symptoms and mood disturbance, and low levels of activity) that increases dramatically following conditioning, reaching a peak approximately 1 week following transplant; (2) this increased distress is transient, declining rapidly back to admission levels by week +4 to week +5, followed by a further decline to presumed basal levels by months 4-6; and (3) the trajectories of distress depicted by both parent and child report are remarkably similar, each providing confirmatory support for the validity of the findings. These findings confirm a number of widely held clinical impressio...Continue Reading

Associated Clinical Trials

References

Nov 1, 1991·Journal of the American Academy of Child and Adolescent Psychiatry·M L StuberS Cohen
Aug 1, 1990·Journal of Pediatric Psychology·S Phipps, S DeCuir-Whalley
Dec 1, 1990·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·B J McConvilleD Woodman
Jul 1, 1994·Journal of Pediatric Oncology Nursing : Official Journal of the Association of Pediatric Oncology Nurses·S PhippsG L Bell
Jun 15, 1994·Statistics in Medicine·S R LipsitzL Zhao
Mar 28, 1996·The New England Journal of Medicine·M A Testa, D C Simonson
Aug 1, 1996·Journal of Pediatric Psychology·R W ButlerB A Handwerger
Apr 1, 1996·Journal of Pediatric Psychology·L E Spieth, C V Harris
Apr 29, 1998·Statistics in Medicine·D L FaircloughV Chang
Jun 26, 1998·Journal of Pediatric Psychology·K VannattaK Koontz
Mar 17, 1999·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·M GünterT Klingebiel
Dec 1, 1999·Bone Marrow Transplantation·A K SullivanL H Hoffman
Feb 16, 2000·Bone Marrow Transplantation·T SasakiM Atsumi
Feb 19, 2000·International Journal of Cancer. Supplement = Journal International Du Cancer. Supplement·S PhippsD K Srivastiva
Feb 19, 2000·International Journal of Cancer. Supplement = Journal International Du Cancer. Supplement·S K ParsonsS H Kaplan
Sep 12, 2000·Bone Marrow Transplantation·M BarreraF Saunders

❮ Previous
Next ❯

Citations

Jul 3, 2009·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·C M J Vrijmoet-WiersmaM A Grootenhuis
Aug 23, 2005·European Journal of Oncology Nursing : the Official Journal of European Oncology Nursing Society·Argerie TsimicalisBonnie Stevens
Nov 11, 2010·Journal of Pediatric Hematology/oncology·Jeanne M EricksonKamar Godder
Mar 24, 2012·Journal of Pediatric Hematology/oncology·Julia A KearneyFarid Boulad
Jul 11, 2013·Journal of Developmental and Behavioral Pediatrics : JDBP·Hala FakhryWaguih William IsHak
Apr 7, 2005·Bone Marrow Transplantation·J J OrtegaA Llort
Oct 3, 2012·European Journal of Oncology Nursing : the Official Journal of European Oncology Nursing Society·Hanne Bækgaard LarsenLis Adamsen
Feb 24, 2016·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Christina K UllrichJoanne Wolfe
Jul 28, 2009·Journal of Pediatric Nursing·Jeanne M Erickson
May 28, 2008·Best Practice & Research. Clinical Haematology·K Scott Baker, Christopher J Fraser
Jul 22, 2004·Pediatric Blood & Cancer·Sean PhippsShesh N Rai
Oct 7, 2010·Psycho-oncology·Sunita K PatelJudith K Sato
Sep 22, 2011·Pediatrics International : Official Journal of the Japan Pediatric Society·Kazumi HiguchiKenichi Koike
May 28, 2011·Pediatric Blood & Cancer·Grace ChangSusan K Parsons
Jan 16, 2014·Nursing & Health Sciences·Arpi ManookianMonireh Asadi
Jan 18, 2014·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Jennifer J LindwallSean Phipps
Oct 17, 2013·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Norma TerrinSusan K Parsons
Nov 20, 2012·Journal of Pediatric Oncology Nursing : Official Journal of the Association of Pediatric Oncology Nurses·Nicole C RosipalG Stephen Morris
Mar 3, 2007·Journal of Pediatric Oncology Nursing : Official Journal of the Association of Pediatric Oncology Nurses·Suzanne L Nuss, Margaret E Wilson
Jun 4, 2011·Journal of Pediatric Oncology Nursing : Official Journal of the Association of Pediatric Oncology Nurses·Elizabeth M Tanzi
Sep 25, 2017·Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence·Nicole B BeckmannPaul J Orchard
Dec 22, 2004·Journal of Pediatric Psychology·Andrea Farkas Patenaude, Mary Jo Kupst
Feb 21, 2019·Pediatric Transplantation·Raphaël CavadiniOlivier Taïeb
Jul 25, 2018·Global Advances in Health and Medicine : Improving Healthcare Outcomes Worldwide·Greta J YatesMichael J Silverman
Aug 28, 2019·Global Advances in Health and Medicine : Improving Healthcare Outcomes Worldwide·E Anne LownFrederick M Hecht

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.