Acute heart failure.

Nature Reviews. Disease Primers
Mattia ArrigoAlexandre Mebazaa

Abstract

Acute heart failure (AHF) is a syndrome defined as the new onset (de novo heart failure (HF)) or worsening (acutely decompensated heart failure (ADHF)) of symptoms and signs of HF, mostly related to systemic congestion. In the presence of an underlying structural or functional cardiac dysfunction (whether chronic in ADHF or undiagnosed in de novo HF), one or more precipitating factors can induce AHF, although sometimes de novo HF can result directly from the onset of a new cardiac dysfunction, most frequently an acute coronary syndrome. Despite leading to similar clinical presentations, the underlying cardiac disease and precipitating factors may vary greatly and, therefore, the pathophysiology of AHF is highly heterogeneous. Left ventricular diastolic or systolic dysfunction results in increased preload and afterload, which in turn lead to pulmonary congestion. Fluid retention and redistribution result in systemic congestion, eventually causing organ dysfunction due to hypoperfusion. Current treatment of AHF is mostly symptomatic, centred on decongestive drugs, at best tailored according to the initial haemodynamic status with little regard to the underlying pathophysiological particularities. As a consequence, AHF is still as...Continue Reading

References

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Citations

May 18, 2020·Journal of Personalized Medicine·Serkan Yüksel, Esra Pancar Yüksel
Dec 6, 2020·International Journal of Clinical Practice·Wesam MullaAnan Younis
Sep 7, 2020·Cellular Signalling·Dylan O'TooleTamara P Martin
Oct 12, 2020·Pharmacology & Therapeutics·Chunhui ZhaoLuqi Huang
Apr 15, 2021·Hellenic Journal of Cardiology : HJC = Hellēnikē Kardiologikē Epitheōrēsē·Simon Tual-Chalot, Konstantinos Stellos
May 14, 2021·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Amr AbdinMichael Böhm
May 14, 2021·Circulation Research·Joyce N Njoroge, John R Teerlink
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Jul 3, 2021·International Journal of Molecular Sciences·Vilbert SikorskiEsko Kankuri
Jul 25, 2021·International Journal of Molecular Sciences·Natthaphat Siri-AngkulJudith K Gwathmey
Jul 20, 2021·Diabetes Research and Clinical Practice·Alfredo CaturanoFerdinando Carlo Sasso

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BETA
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ADHERE

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