PMID: 3763244Apr 1, 1986Paper

Acute hematogenous staphylococcal osteomyelitis: the effects of surgical drilling and curettage in an animal model

Pathology
K R Emslie, S M Nade

Abstract

Surgical drilling and curettage of metaphyseal medullary bone were performed in chickens 4, 8 and 15 d after bacterial inoculation with Staphylococcus aureus producing osteomyelitis. Intramedullary drilling and curettage resulted in extensive vascular damage and necrosis of medullary bone but failed to remove all viable bacteria. An effective continuing drainage channel for the pus was not established due to the formation of blood clot within the drill hole. Surgery performed before the formation of a sequestrum resulted in further spread of bacteria within the medullary cavity and the formation of a larger sequestrum than that commonly observed in the bones of infected, untreated chickens. Surgery performed after the formation of a sequestrum destroyed the abscess wall thus disrupting a natural defence mechanism of the host. Whilst a direct comparison of surgical drilling in human osteomyelitis and in this avian model cannot be made, the results suggest that production of an artificial drill hole across the cortex and curettage of the bone in human osteomyelitis would be destructive and may not be warranted.

References

Nov 1, 1975·American Journal of Diseases of Children·V Q DichK C Haltalin
Nov 1, 1970·The Journal of Infectious Diseases·C W Norden
Oct 1, 1983·The Journal of Pathology·K R EmslieS M Nade
Jan 1, 1982·The Journal of Bone and Joint Surgery. British Volume·W G ColeS Leitl
Mar 1, 1954·The British Journal of Surgery·J TRUETA, J D MORGAN
May 26, 1962·British Medical Journal·N H HARRIS

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Citations

Apr 22, 2008·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Xie-Yi CaiMin Zhu
May 18, 2006·The International Journal of Artificial Organs·Y H AnC R Arciola

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