PMID: 7581157Aug 1, 1995Paper

Acute hemolysis during cyclosporine therapy successfully treated with vitamin E

Bone Marrow Transplantation
E AzumaM Sakurai

Abstract

The immunosuppressant cyclosporine induces acute hemolysis (hemolytic uremic syndrome) in some patients after transplantation, possibly because of its effects on the vascular endothelium. We report a case of Coombs-negative, non-immune severe hemolytic anemia during cyclosporine therapy after allogeneic bone marrow transplantation for severe aplastic anemia. Uremia was not observed. Vitamin E was effective in treating the intravascular hemolysis.

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